Tolbutamide
[CAS# 64-77-7]

Identification

• Classification: API >> Hormone and endocrine-regulating drugs >> Pancreatic hormones and other blood sugar regulating drugs
• Name: Tolbutamide
• Synonyms: 1-Butyl-3-(4-Methylphenyl)Sulfonyl-Urea; Ninds_000341; Zinc01530703
• Molecular Formula: C₁₂H₁₈N₂O₃S
• Molecular Weight: 270.35
• CAS Registry Number: 64-77-7
• EINECS: 200-594-3
• SMILES: C1=C([S](NC(NCCCC)=O)(=O)=O)C=CC(=C1)C
• InChI: 1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
• InChIKey: JLRGJRBPOGGCBT-UHFFFAOYSA-N

Properties

• Density: 1.2±0.1g/cm³ (Cal.)
• Melting point: 128-129°C (Expl.)

Safety Data

• Safety Code: S24;S37
• Risk Code: R43
• Hazard Symbol: X
• Safety Description: WARNING: May cause irritation, skin or lung sensitization.

References

• (1): Anastasia Paulidou, Davide Maffeo, Konstantina Yannakopoulou and Irene M. Mavridis. Similar modes of inclusion in complexes of β-cyclodextrin with sulfonylurea hypoglycemic drugs, CrystEngComm, 2010, 12, 517.