Ibuprofen
[CAS# 15687-27-1]

Identification

• Classification: API >> Antipyretic analgesics >> Non-steroidal anti-inflammatory drugs
• Name: Ibuprofen
• Synonyms: alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid; 2-(4-Isobutylphenyl)-propionic acid; p-Isobutylhydratropic acid
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.28
• CAS Registry Number: 15687-27-1
• EC Number: 239-784-6

Properties

• Melting point: 75-78 °C
• Boiling point: 157 °C (4 mmHg)
• Water solubility: insoluble

Safety Data

• Hazard Symbols: Xn;N
• Risk Statements: R22;R51/53;R63
• Safety Statements: S36/37;S61

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Reproductive toxicity	Repr.	2	H361
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Specific target organ toxicity - single exposure	STOT SE	2	H371
Reproductive toxicity	Repr.	1A	H360
Skin irritation	Skin Irrit.	2	H315
Reproductive toxicity	Repr.	1B	H360
Eye irritation	Eye Irrit.	2A	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Chronic hazardous to the aquatic environment	Aquatic Chronic	4	H413
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H332
Reproductive toxicity	Repr.	1B	H360D
Skin mild irritation	Skin Mild Irrit. 99	3	H316
Specific target organ toxicity - repeated exposure	STOT RE	1	H372
Skin sensitization	Skin Sens.	1	H317

Discovery and Applications

1. Synthesis: Adams, S. S., et al. (1967). "The synthesis and some properties of ibuprofen." Journal of Pharmacy and Pharmacology, 19(9), 590-596.
DOI: 10.1111/j.2042-7158.1967.tb09584.x

2. Applications: Derry, S., et al. (2013). "Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain." Cochrane Database of Systematic Reviews, (6), CD010210.
DOI: 10.1002/14651858.CD010210.pub2

3. Review: Moore, R. A., et al. (2015). "Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions." European Journal of Pain, 19(9), 1213-1223.
DOI: 10.1002/ejp.649