JackiePhos Pd G3
[CAS# 2102544-35-2]

Identification

• Classification: Organic raw materials >> Organometallic compound >> Organic palladium
• Name: JackiePhos Pd G3
• Synonyms: [2'-(Amino-?N)[1,1'-biphenyl]-2-yl-?C][bis[3,5-bis(trifluoromethyl)phenyl][3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine-?P](methanesulfonato-?O)palladium
• Molecular Formula: C₅₂H₅₁F₁₂NO₅PPdS^-
• Molecular Weight: 1167.40
• CAS Registry Number: 2102544-35-2
• SMILES: CS(=O)(=O)O[Pd]c1ccccc1-c2ccccc2N.COc3ccc(OC)c(c3P(c4cc(cc(c4)C(F)(F)F)C(F)(F)F)c5cc(cc(c5)C(F)(F)F)C(F)(F)F)-c6c(cc(cc6C(C)C)C(C)C)C(C)C

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H312-H332
• Safety Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Discovery and Applications

JackiePhos Pd G3 is a sophisticated organometallic compound widely recognized for its role as an efficient catalyst in organic synthesis. This complex consists of a palladium center coordinated with JackiePhos, a highly specialized ligand known for its remarkable properties and versatility in various chemical reactions.

The discovery of JackiePhos Pd G3 emerged from ongoing efforts to develop advanced palladium catalysts with enhanced performance. JackiePhos, short for 2-(di-tert-butylphosphino)biphenyl, is known for its ability to stabilize palladium centers and influence the reactivity of the metal. The G3 designation indicates a specific generation of this ligand, incorporating design improvements to further enhance its catalytic efficiency.

JackiePhos Pd G3 is particularly valued for its application in cross-coupling reactions, such as the Suzuki-Miyaura and Negishi coupling reactions. These reactions are fundamental in the formation of carbon-carbon bonds, which are crucial for synthesizing complex organic molecules used in pharmaceuticals, materials science, and other industrial applications. The JackiePhos ligand provides excellent stability and reactivity, enabling these reactions to proceed with high selectivity and efficiency.

One of the key advantages of JackiePhos Pd G3 is its ability to catalyze reactions under mild conditions. This feature is particularly important when working with sensitive substrates or when aiming to control reaction conditions precisely. The ligand's design allows it to accommodate a wide range of functional groups, making it a versatile tool in synthetic chemistry.

In addition to cross-coupling reactions, JackiePhos Pd G3 finds applications in other palladium-catalyzed processes. Its effectiveness extends to various transformations, including oxidative addition and reductive elimination, where it contributes to the formation of new carbon-carbon and carbon-heteroatom bonds.

Overall, JackiePhos Pd G3 represents a significant advancement in palladium-catalyzed chemistry. Its discovery has provided researchers and industrial chemists with a valuable tool for conducting efficient and selective reactions, further advancing the field of organic synthesis and materials science.

References

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