Sorbitan Tristearate
[CAS# 26658-19-5]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate
• Name: Sorbitan Tristearate
• Synonyms: 1,3,6-Tri-O-stearoylhexitol
• Molecular Formula: C₆₀H₁₁₆O₉
• Molecular Weight: 981.56
• CAS Registry Number: 26658-19-5
• EC Number: 247-891-4
• SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(O)C(O)C(OC(=O)CCCCCCCCCCCCCCCCC)C(O)COC(=O)CCCCCCCCCCCCCCCCC

Properties

• Density: 1.0±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.478, Calc.^*
• Boiling Point: 921.5±65.0 ºC (760 mmHg), Calc.^*
• Flash Point: 231.6±27.8 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315

Discovory and Applicatios

Sorbitan tristearate is a nonionic surfactant and emulsifier derived from sorbitol and stearic acid. It belongs to the class of sorbitan esters, which are widely used in various industrial and commercial applications. The compound is synthesized through the esterification of sorbitol with stearic acid, resulting in a molecule that has both hydrophilic and lipophilic properties. This amphiphilic nature makes it highly effective in stabilizing emulsions and dispersions.

One of the primary applications of sorbitan tristearate is in the food industry, where it functions as an emulsifier to improve the texture and consistency of various products. It is commonly used in baked goods, margarine, and confectionery to enhance fat dispersion and prevent ingredient separation. Its role in emulsification is particularly beneficial in products that require stable oil-in-water or water-in-oil mixtures. Regulatory authorities in many countries have approved its use as a food additive, often designated under the E number E492.

Sorbitan tristearate is also widely used in the cosmetics and pharmaceutical industries. In cosmetic formulations, it serves as an emulsifying agent in creams, lotions, and other personal care products, helping to blend oil- and water-based ingredients. Its stability and compatibility with various ingredients make it a valuable component in skincare and haircare formulations. In pharmaceutical applications, it is used as an excipient in drug formulations to improve the consistency and delivery of active ingredients.

In industrial applications, sorbitan tristearate is utilized in the production of plastics, coatings, and lubricants. It can act as a dispersing agent, preventing the aggregation of particles in polymer blends and enhancing the processing of materials. Additionally, it finds use in textile and agricultural formulations, where its emulsifying properties contribute to the stability and performance of certain chemical preparations.

Sorbitan tristearate is considered safe for use in its approved applications, with a low toxicity profile. It is biodegradable and generally well tolerated in food and cosmetic products. However, its use is subject to regulatory guidelines that specify acceptable concentrations in different formulations. Due to its effectiveness in stabilizing emulsions and modifying surface properties, sorbitan tristearate continues to be a key ingredient across multiple industries.