Cy7 DiC18
[CAS# 100068-60-8]

Identification

• Name: Cy7 DiC18
• Synonyms: diIC18(7) dye; DiR; 2-[7-(3,3-dimethyl-1-octadecylindol-1-ium-2-yl)hepta-2,4,6-trienylidene]-3,3-dimethyl-1-octadecylindole iodide
• Molecular Formula: C₆₃H₁₀₁IN₂
• Molecular Weight: 1013.39
• CAS Registry Number: 100068-60-8
• SMILES: CCCCCCCCCCCCCCCCCCN1C2=CC=CC=C2C(C1=CC=CC=CC=CC3=[N+](C4=CC=CC=C4C3(C)C)CCCCCCCCCCCCCCCCCC)(C)C.[I-]

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Discovory and Applicatios

Cy7 DiC18 is a cyanine dye, scientifically known as a heptamethine cyanine dye, which has attracted much attention for its applications in biomedical imaging and photodynamic therapy. The molecular structure of this compound is a conjugated system of seven methine groups, which has unique optical properties that make it invaluable in modern scientific research and clinical applications.

The discovery of Cy7 DiC18 stems from the exploration of cyanine dyes that began in the mid-19th century. Cyanine dyes are organic compounds whose polymethine bridge is flanked by two nitrogen-containing heterocyclic rings. Specifically, Cy7 DiC18 belongs to the class of heptamethine cyanine dyes, which are characterized by an extended conjugated system that leads to longer wavelength absorption and emission, typically in the near-infrared (NIR) region. This NIR range (approximately 700-900 nm) is particularly useful for bioimaging because it minimizes absorption in biological tissues and allows deeper tissue penetration while reducing background interference.

The structure of Cy7 DiC18 enables it to absorb and emit light in the NIR spectrum. This property is critical for its role in fluorescence imaging, where it serves as a marker for detection with high sensitivity and specificity. The dye's conjugation system results in strong absorbance in the NIR range, making it ideal for applications requiring minimal autofluorescence and deep tissue imaging.

Cy7 DiC18 is widely used for in vivo imaging due to its NIR fluorescence properties. Its ability to penetrate deep tissues allows researchers and clinicians to visualize internal structures and processes at high resolution. It is particularly valuable in tumor imaging, helping to identify cancerous tissue and monitor tumor growth and metastasis.

In addition to imaging, Cy7 DiC18 has potential for photodynamic therapy, a treatment that uses light-activated compounds to generate reactive oxygen species that can kill cancer cells. When Cy7 DiC18 is irradiated with NIR light, it can induce localized cell damage in a targeted area, providing a minimally invasive treatment option for certain cancers.

The dye's chemical versatility allows it to be conjugated to a variety of biomolecules, creating molecular probes for detecting specific proteins or other targets within cells. This makes Cy7 DiC18 a valuable tool for studying cellular function and diagnosing disease at the molecular level.

In addition to direct applications, Cy7 DiC18 is also being explored in the development of advanced drug delivery systems. Its fluorescent properties help track the distribution and release of therapeutic agents in real time, thereby promoting more precise and effective treatments.