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Homosalate
[CAS# 118-56-9]

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Changzhou Tianhua Pharmaceutical Co., Ltd. China Inquire  
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Complete supplier list of Homosalate
Identification
Classification Analytical chemistry >> Standard >> Volatile organic compounds (VOCs)
Name Homosalate
Synonyms 3,3,5-Trimethylcyclohexyl salicylate; Homomenthyl salicylate; Trimethylcyclohenyl salicylate
Molecular Structure CAS # 118-56-9, Homosalate, 3,3,5-Trimethylcyclohexyl salicylate, Homomenthyl salicylate, Trimethylcyclohenyl salicylate
Molecular Formula C16H22O3
Molecular Weight 262.35
CAS Registry Number 118-56-9
EC Number 204-260-8
SMILES CC1CC(CC(C1)(C)C)OC(=O)C2=CC=CC=C2O
Properties
Solubility <0.1 g/100 mL (water 26 ºC), 55mg/mL (DNSO)
Density 1.1±0.1 g/cm3, Calc.*
Index of Refraction 1.539, Calc.*
Boiling Point 341.1±15.0 ºC (760 mmHg), Calc.*, 161-165 ºC (12 torr)
Flash Point 132.3±13.2 ºC, Calc.*
* Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbols symbol symbol symbol   GHS07;GHS08;GHS09 Warning    Details
Hazard Statements H315-H319-H335-H361d-H410    Details
Precautionary Statements P203-P261-P264-P264+P265-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P318-P319-P321-P332+P317-P337+P317-P362+P364-P391-P403+P233-P405-P501    Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Specific target organ toxicity - single exposureSTOT SE3H335
Skin irritationSkin Irrit.2H315
Eye irritationEye Irrit.2H319
Reproductive toxicityRepr.2H361d
Chronic hazardous to the aquatic environmentAquatic Chronic1H410
Chronic hazardous to the aquatic environmentAquatic Chronic4H413
SDS Available
up Discovory and Applicatios
Homosalate, also known as homosalate, is a chemical compound recognized primarily for its role in the formulation of sunscreen products. Its chemical formula is C11H14O3, and it belongs to a class of chemicals known as esters. The compound is derived from salicylic acid, and its synthesis can be traced back to the mid-20th century when the cosmetic industry began to explore more effective UV filters. Homosalate emerged as a promising candidate due to its ability to absorb ultraviolet (UV) radiation, thus protecting the skin from harmful effects.

The discovery of homosalate was part of a broader effort to develop safer and more effective sun protection agents. Researchers found that homosalate possesses a broad absorption spectrum, particularly effective in filtering out UVB radiation, which is primarily responsible for sunburn and contributes to skin cancer. As a result, it became a common ingredient in many sunscreen formulations, often used in conjunction with other UV filters to enhance overall protection.

In the cosmetic industry, homosalate serves multiple functions beyond UV absorption. It acts as a solvent and a skin conditioning agent, improving the texture and feel of sunscreen products. This versatility makes it a valuable component in the formulation of not only sunscreens but also other personal care products, such as moisturizers and makeup, where sun protection is desired.

Homosalate is typically found in concentrations ranging from 10% to 15% in sunscreen formulations. Its efficacy as a UV filter is enhanced when combined with other sunscreen agents, such as octocrylene and avobenzone, creating a synergistic effect that broadens the spectrum of UV protection. Moreover, the stability of homosalate under sunlight makes it a favorable choice for outdoor applications, as it maintains its protective qualities during sun exposure.

Despite its widespread use, homosalate has faced scrutiny regarding its safety and environmental impact. Concerns have been raised about the potential for hormone disruption and bioaccumulation in marine ecosystems. Regulatory bodies, including the U.S. Food and Drug Administration (FDA) and the European Commission, have established guidelines for the safe use of homosalate in cosmetic products. These regulations emphasize the importance of conducting safety assessments to evaluate potential health risks associated with its use.

In recent years, the demand for natural and organic products has prompted the development of alternative UV filters. However, homosalate remains a popular choice in many conventional formulations due to its effectiveness and stability. Ongoing research continues to explore its properties and potential applications in other areas, such as pharmaceuticals and materials science.

In summary, homosalate is a significant chemical compound in the field of sun protection, recognized for its role as a UV filter in sunscreen formulations. Its discovery in the mid-20th century marked a pivotal moment in the cosmetic industry, contributing to advancements in skin safety. While its effectiveness and versatility have cemented its place in personal care products, ongoing research into its safety profile underscores the need for responsible use and development of alternatives in response to consumer preferences.
Market Analysis Reports
List of Reports Available for Homosalate
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