Copper glycinate
[CAS# 13479-54-4]

Identification

• Classification: Biochemical >> Common amino acids and protein drugs
• Name: Copper glycinate
• Synonyms: Bis(glycinato)copper
• Molecular Formula: C₄H₈CuN₂O₄
• Molecular Weight: 211.66
• CAS Registry Number: 13479-54-4
• EC Number: 236-783-2
• SMILES: C(C(=O)[O-])N.C(C(=O)[O-])N.[Cu+2]

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Hazard Statements: H302-H315-H317-H319-H400
• Precautionary Statements: P261-P264-P264+P265-P270-P272-P273-P280-P301+P317-P302+P352-P305+P351+P338-P321-P330-P332+P317-P333+P317-P337+P317-P362+P364-P391-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Skin sensitization	Skin Sens.	1	H317
Specific target organ toxicity - single exposure	STOT SE	3	H335
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410

Discovory and Applicatios

Copper glycinate is a coordination compound in which copper(II) ions are complexed with the amino acid glycine (NH₂CH₂COOH). Its empirical composition is typically represented as Cu(C₂H₄NO₂)₂·xH₂O, where the degree of hydration depends on preparation and storage conditions. The molecule contains bidentate glycine ligands, each coordinating to the copper ion through the nitrogen atom of the amino group and the oxygen atom of the carboxylate group, forming a chelate ring that imparts good stability to the complex.

The synthesis of copper glycinate is generally achieved by reacting an aqueous solution of glycine with a soluble copper(II) salt, such as copper(II) sulfate or copper(II) acetate, under controlled pH conditions to promote chelation and minimize hydrolysis to copper hydroxide. The complex can be isolated by evaporation, crystallization, or precipitation, and is usually obtained as a blue to blue-green crystalline solid. The formation of such amino acid–metal complexes has been well established in coordination chemistry since the early 20th century, with copper glycinate serving as a representative model for studying metal–protein binding in biological systems.

Copper glycinate has been investigated and used primarily as a dietary supplement in animal nutrition. Copper is an essential trace mineral required for enzyme function, hemoglobin synthesis, connective tissue development, and immune competence. Chelated forms such as copper glycinate are often promoted for their potentially higher bioavailability compared to inorganic salts like copper sulfate, as the amino acid ligand can protect the copper from forming insoluble precipitates in the digestive tract. This property can be particularly advantageous in feeds containing high levels of antagonistic minerals such as molybdenum, sulfur, or iron, which can otherwise reduce copper absorption.

In veterinary and livestock applications, copper glycinate is used in feed premixes, mineral supplements, and sometimes in injectable formulations to correct copper deficiencies, which can manifest as anemia, poor growth, loss of hair pigmentation, and impaired reproduction. It has been evaluated in ruminants, swine, poultry, and companion animals, with research focusing on its effects on copper status, growth performance, and health parameters.

Beyond animal nutrition, copper glycinate has been studied for potential biomedical applications, including its role as an antioxidant and anti-inflammatory agent due to copper’s involvement in superoxide dismutase activity. Laboratory studies have also used copper glycinate as a model compound to understand metal–amino acid interactions in proteins and enzymes, contributing to the broader understanding of metalloprotein structure and function.

While copper glycinate is generally safe when used at recommended levels, excess copper intake can lead to toxicity, characterized by liver damage, oxidative stress, and gastrointestinal disturbances. Therefore, formulation in feeds or supplements must adhere to established regulatory guidelines, balancing essential supply with avoidance of overload.

References

2015. Sugar-Conjugated Bis(glycinato)copper(II) Complexes and Their Modulating Influence on the Maillard Reaction. Journal of Agricultural and Food Chemistry, 63(16).
DOI: 10.1021/acs.jafc.5b00932

2010. Insight in the transport behavior of copper glycinate complexes through the porcine gastrointestinal membrane using an Ussing chamber assisted by mass spectrometry analysis. Journal of Trace Elements in Medicine and Biology, 24(2).
DOI: 10.1016/j.jtemb.2009.11.005

2008. Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum. Journal of Animal Science, 86(1).
DOI: 10.2527/jas.2006-814