2-Methyl-4-nitropyridine
[CAS# 13508-96-8]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyridine compound >> Nitropyridine
• Name: 2-Methyl-4-nitropyridine
• Synonyms: 4-Nitro-2-picoline
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12
• CAS Registry Number: 13508-96-8
• EC Number: 640-476-2
• SMILES: CC1=NC=CC(=C1)[N+](=O)[O-]

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Hazard Statements: H302-H318
• Precautionary Statements: P264-P264+P265-P270-P280-P301+P317-P305+P354+P338-P317-P330-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Serious eye damage	Eye Dam.	1	H318
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2A	H319
Eye irritation	Eye Irrit.	2	H319
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H332

Discovory and Applicatios

2-Methyl-4-nitropyridine, a chemical compound commonly known as 2M4NP, was first synthesized in the early 20th century through organic synthesis methods. Its discovery emerged from the exploration of various pyridine derivatives, driven by the desire to develop compounds with diverse industrial and pharmaceutical applications.

2M4NP serves as a key intermediate in the synthesis of several agrochemicals, including pesticides and herbicides. Its versatility allows for the modification of chemical structures to enhance efficacy.

Pharmaceutical researchers utilize 2M4NP as a building block in the synthesis of various drug compounds. Its chemical reactivity enables the introduction of functional groups necessary for the development of pharmaceuticals targeting diverse therapeutic areas.

In organic chemistry, 2M4NP serves as a valuable reagent for the preparation of complex molecules. Its ability to undergo diverse chemical transformations, such as reduction, substitution, and functional group interconversion, makes it indispensable in the synthesis of fine chemicals, natural products, and specialty compounds.

2M4NP finds applications in material science, particularly in the preparation of advanced materials and polymers. By incorporating 2M4NP-derived moieties into polymer chains, researchers can tailor material properties such as mechanical strength, thermal stability, and conductivity.

2M4NP serves as a reference standard in analytical chemistry for the calibration and quantification of pyridine derivatives in various samples. Its well-defined chemical structure and stability make it a reliable tool for chromatographic analysis, environmental monitoring, and quality control in industries ranging from pharmaceuticals to petrochemicals.

References

2020. Denitrative functionalization of nitroarenes. Journal of the Iranian Chemical Society, 18(3).
DOI: 10.1007/s13738-020-02054-2

2012. Quantitative relations holding in coordination of (Tetraphenylporphyrinato)zinc(II) and nucleophilic substitution with anilines. Russian Journal of Organic Chemistry, 48(6).
DOI: 10.1134/s1070428012060048

2011. Nitropyridines 11. *Recyclization of quaternary nitropyridinium salts into substituted nitroanilines. Chemistry of Heterocyclic Compounds, 47(4).
DOI: 10.1007/s10593-011-0783-3