Magnesium bisglycinate
[CAS# 14783-68-7]

Identification

• Classification: Biochemical >> Common amino acids and protein drugs
• Name: Magnesium bisglycinate
• Synonyms: Magnesium chelazome; Bis(glycinato)magnesium
• Molecular Formula: C₄H₈MgN₂O₄
• Molecular Weight: 172.42
• CAS Registry Number: 14783-68-7
• EC Number: 238-852-2
• SMILES: C(C(=O)[O-])N.C(C(=O)[O-])N.[Mg+2]

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H317-H319
• Precautionary Statements: P280-P305+P351+P338

Discovory and Applicatios

Magnesium bisglycinate is a chelated form of magnesium that was developed during the early to mid-20th century from basic research in chelation chemistry to improve magnesium bioavailability and gastrointestinal tolerance. At the time, it was discovered that combining minerals with amino acids could improve their absorption in the body. Magnesium bisglycinate is formed by the reaction of magnesium with the amino acid glycine, producing a compound that is more easily absorbed than inorganic magnesium salts.

Magnesium bisglycinate is commonly used as a dietary supplement due to its high bioavailability and low gastrointestinal side effects. It is preferred over other magnesium salts because it is effectively absorbed without causing a laxative effect. These supplements are available in a variety of forms, including capsules, tablets, and powders, to support adequate magnesium intake and overall health.

Magnesium bisglycinate is used to support muscle function and recovery and is popular among athletes and the fitness community. Magnesium plays an important role in muscle contraction and relaxation, and adequate intake helps prevent cramps, spasms, and muscle fatigue. Magnesium bisglycinate is used in sports nutrition products to promote muscle health and enhance recovery after exercise.

Magnesium bisglycinate is used in sleep support formulas to improve sleep quality and duration. Magnesium affects the regulation of sleep-related neurotransmitters, such as GABA (gamma-aminobutyric acid). The calming effects of magnesium bisglycinate on the nervous system help reduce stress and anxiety and promote a relaxing, restful sleep. It is often found in sleep aids and sedative supplements.

Magnesium glycinate aids calcium absorption and supports bone mineralization, which promotes bone health. Magnesium is essential for the structural development of bones and teeth and helps maintain bone density. Magnesium glycinate is used in bone health supplements along with calcium and vitamin D to support bone strength and reduce the risk of osteoporosis.

Magnesium glycinate supports cardiovascular health by helping regulate blood pressure, heart rhythm, and overall cardiovascular function. Adequate magnesium levels are associated with a reduced risk of high blood pressure, heart rhythm disorders, and other cardiovascular diseases. Magnesium glycinate supplements are used in medications to promote heart health and maintain healthy blood pressure levels.

Magnesium glycinate is used in digestive medications because of its gentle effects on the gastrointestinal system. Unlike other magnesium salts that can cause indigestion, magnesium glycinate is less likely to have a laxative effect and is well tolerated. It is used to address magnesium deficiency and does not cause discomfort or diarrhea, making it suitable for people with sensitive digestive tracts.

Magnesium glycinate is used in supplements to support mental health and cognitive function. Magnesium is involved in many biochemical reactions in the brain, including the synthesis and signaling of neurotransmitters. Adequate magnesium levels aid in mood regulation, cognitive performance, and stress recovery. Magnesium glycinate is used in medications to support cognitive health and mental clarity.

References

1994. Bioavailability of Magnesium Diglycinate vs Magnesium Oxide in Patients with Ileal Resection. JPEN. Journal of parenteral and enteral nutrition, 18, 5.
URL: https://pubmed.ncbi.nlm.nih.gov/7815675

2018. The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products. Scientific Data, 5, 180125.
DOI: 10.1038/sdata.2018.125