Pyridoxine tripalmitate
[CAS# 4372-46-7]

Identification

• Name: Pyridoxine tripalmitate
• Synonyms: [5-hexadecanoyloxy-4-(hexadecanoyloxymethyl)-6-methylpyridin-3-yl]methyl hexadecanoate
• Molecular Formula: C₅₆H₁₀₁NO₆
• Molecular Weight: 884.40
• CAS Registry Number: 4372-46-7
• EC Number: 224-470-3
• SMILES: CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C(=C1COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C

Properties

• Density: 0.9±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.483, Calc.^*
• Boiling Point: 826.1±65.0 ºC (760 mmHg), Calc.^*
• Flash Point: 453.4±34.3 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Discovory and Applicatios

Pyridoxine tripalmitate is a derivative of pyridoxine, also known as vitamin B6. It is synthesized by esterifying pyridoxine with palmitic acid, resulting in a compound with unique properties and applications. The discovery of pyridoxine tripalmitate can be traced back to studies conducted on the biological activities of pyridoxine and its derivatives. Pyridoxine is a water-soluble B vitamin that was first isolated in the early 1930s by a team of scientists led by Paul Gy�rgy. Initially, its role in preventing deficiency diseases such as pellagra and beriberi was recognized. However, further studies revealed its importance in various metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and hemoglobin formation. Pyridoxine tripalmitate was later synthesized to enhance the lipophilicity of pyridoxine, making it more suitable for application in lipid-rich environments, such as cell membranes and lipid-based formulations. The esterification of pyridoxine with palmitic acid increases its solubility in lipids, thereby improving bioavailability and stability. The applications of pyridoxine tripalmitate are diverse and cover a variety of fields, including pharmaceuticals, cosmetics, and nutrition. In the pharmaceutical industry, it is used as a component of lipid drug delivery systems as a carrier for drugs that are less water soluble. Pyridoxine tripalmitate has the ability to penetrate cell membranes, thus allowing for more effective delivery of therapeutics to target tissues. In cosmetics, pyridoxine tripalmitate acts as an emollient to help soften and smooth the skin while also providing antioxidant benefits. Additionally, pyridoxine tripalmitate has been shown to boost collagen synthesis, making it a popular ingredient in anti-aging skin care products. From a nutritional perspective, pyridoxine tripalmitate offers a new way to deliver vitamin B6 to the body. While pyridoxine hydrochloride is commonly used in dietary supplements and fortified foods, its water solubility limits its use in lipid-rich matrices. Pyridoxine tripalmitate overcomes this limitation by providing a lipophilic form of vitamin B6 that can be incorporated into lipid-based foods and supplements. Research into the therapeutic potential of pyridoxine tripalmitate is ongoing, with studies exploring its role in a variety of health conditions. For example, pyridoxine tripalmitate has been studied for its anti-inflammatory properties and potential to relieve symptoms of inflammatory skin diseases such as acne and eczema. In addition, its ability to modulate lipid metabolism and support neurological function makes it a promising candidate for the treatment of neurological diseases such as Alzheimer's and Parkinson's diseases. Overall, pyridoxine tripalmitate represents a new approach to harness the therapeutic benefits of vitamin B6 in a lipid formulation.