N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea
[CAS# 487021-52-3]

Identification

• Classification: Biochemical >> Inhibitor >> PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) >> GSK-3 inhibitor
• Name: N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea
• Synonyms: AR 0133418; AR 014418; AR-AO 14418; GSK 3B Inhibitor VIII; GSK 3beta inhibitor VIII
• Molecular Formula: C₁₂H₁₂N₄O₄S
• Molecular Weight: 308.31
• CAS Registry Number: 487021-52-3
• EC Number: 637-170-6

Properties

• Solubility: Insoluble (8.3E^-3 g/L) (25 ºC), Calc.^*
• Density: 1.464±0.06 g/cm³ (20 ºC 760 Torr), Calc.^*
• Melting point: 211-213 ºC^**

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2013 ACD/Labs)

^** Lo Monte, Fabio; Bioorganic & Medicinal Chemistry Letters 2011, V21(18), P5610-5615.

Safety Data

• Hazard Symbols: Xn
• Risk Codes: R22;R37/38;R41
• Safety Description: S26;S36/39

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	4	H302