5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone monobenzoate (salt)
[CAS# 753498-24-7]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Quinoline compound
• Name: 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone monobenzoate (salt)
• Synonyms: [(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-(2-oxo-8-phenylmethoxy-1H-quinolin-5-yl)ethyl] benzoate
• Molecular Formula: C₃₁H₃₄N₂O₃^.C₇H₆O₂
• Molecular Weight: 604.73
• CAS Registry Number: 753498-24-7
• EC Number: 825-118-7
• SMILES: CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)OCC5=CC=CC=C5)OC(=O)C6=CC=CC=C6)CC

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H315-H319-H335
• Precautionary Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315

Discovory and Applicatios

5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone monobenzoate (salt) is a complex chemical compound developed for its potential therapeutic applications. It represents a class of quinolinone derivatives that have been studied for their unique biological properties. Quinolinones, in general, are known for their diverse pharmacological activities, which include antimicrobial, anticancer, and anti-inflammatory effects. This particular compound, with its intricate structure, was designed to explore new avenues in drug development, focusing on the interaction between quinolinone and amine groups, which are critical for biological activity.

The discovery of this compound can be attributed to the growing interest in quinolinone-based molecules in medicinal chemistry. Quinolinones are an established class of compounds, many of which have shown promise in treating various diseases. Researchers in the field of drug design have sought to enhance the effectiveness of these molecules by modifying their structure to improve selectivity, potency, and solubility. The introduction of dihydro-indenyl and phenylmethoxy groups into the quinolinone framework represents an effort to increase the compound’s bioactivity while ensuring that it can be efficiently absorbed by the body. The use of the monobenzoate salt form further aids in the solubility of the compound, making it more suitable for pharmaceutical formulations.

In terms of applications, 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone monobenzoate (salt) has been investigated primarily for its potential as an anticancer agent. Quinolinone derivatives have been widely recognized for their ability to interfere with DNA replication and cell cycle progression in cancer cells, making them valuable candidates for cancer therapy. The specific modifications in this compound, such as the addition of the dihydro-indenyl group, are designed to increase its interaction with cellular targets involved in the regulation of cell growth and apoptosis. This compound has shown potential in preclinical studies as a targeted anticancer agent, although further research is necessary to establish its efficacy in human clinical trials.

Moreover, the compound's anti-inflammatory properties, derived from its quinolinone core, also make it a candidate for the treatment of inflammatory diseases. Its ability to modulate key inflammatory pathways may help in the development of therapies for conditions such as rheumatoid arthritis and inflammatory bowel disease. However, the full therapeutic spectrum of this compound is still under investigation, with ongoing studies aimed at determining its safety, bioavailability, and mechanism of action.

The development of this compound highlights the importance of synthetic chemistry in drug discovery. By modifying existing molecular frameworks, researchers can create new compounds with improved pharmacological profiles. Although still in the research phase, 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone monobenzoate (salt) has the potential to contribute to the treatment of cancer and inflammatory diseases, opening new therapeutic possibilities.