Hydroxyethyl Cellulose
[CAS# 9004-62-0]

Identification

• Classification: Surfactant >> Nonionic surfactant >> Polyol ester type
• Name: Hydroxyethyl Cellulose
• Synonyms: Hydroxyethyl cellulose ether
• CAS Registry Number: 9004-62-0
• EC Number: 618-387-5
• SMILES: O1C(C(C(C(C1CO)OC)O)OCCO)OC2C(OC(C(C2O)O)OC4C(OC(C(C4O)O)C)CO)COC3OC(C(C(C3O)O)OC)CO

Properties

• Density: 0.6 g/mL (25 ºC)

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302
• Precautionary Statements: P280-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H332
Acute toxicity	Acute Tox.	4	H302
Acute toxicity	Acute Tox.	4	H312

Discovory and Applicatios

Hydroxyethyl cellulose (HEC) is a water-soluble polymer derived from cellulose, a natural polysaccharide found in the cell walls of plants. It was first synthesized in the 1950s through the reaction of cellulose with ethylene oxide, which introduces hydroxyethyl groups into the cellulose structure. The introduction of these groups enhances the solubility of cellulose in water, making HEC a versatile material with a wide range of applications.

One of the most common uses of hydroxyethyl cellulose is in the pharmaceutical industry, where it is employed as a thickening agent, binder, and film-forming agent in various formulations. It is widely used in the production of oral pharmaceutical tablets, where it serves as a binder to hold the active ingredients together, ensuring the stability of the tablet. HEC is also used in topical drug formulations, such as gels and creams, to improve the consistency and viscosity of the products, allowing for better application and controlled release of active compounds.

In the cosmetic and personal care industries, hydroxyethyl cellulose is frequently used as a thickener, emulsifier, and stabilizer in products such as shampoos, conditioners, lotions, and creams. Its ability to form clear gels and increase the viscosity of solutions makes it particularly useful in personal care products. HEC is also valued for its mildness, making it suitable for use in formulations for sensitive skin.

Hydroxyethyl cellulose is commonly used in the construction and building materials industry, particularly in cement-based products, such as adhesives, sealants, and grouts. It acts as a water retention agent, helping to improve the workability and adjust the drying time of these materials. Its ability to enhance the flow properties of cement mixtures makes it easier to apply and increases the performance of the final product.

In the food industry, hydroxyethyl cellulose is used as a thickening agent and stabilizer in products like sauces, dressings, and dairy products. It is effective in maintaining the consistency and preventing the separation of ingredients in emulsions, ensuring a smooth texture in processed foods.

Another significant application of HEC is in the oil and gas industry, where it is used as a viscosifier in drilling fluids. In this context, hydroxyethyl cellulose improves the flow properties of drilling muds, enabling them to carry drilling cuttings to the surface more effectively while maintaining the stability of the wellbore.

HEC is also employed in the textile industry, where it serves as a sizing agent for fabric, improving the strength, smoothness, and feel of textiles. It is used in various other industrial applications, including coatings and paints, where it enhances the rheological properties of the formulations.

Despite its widespread use, hydroxyethyl cellulose is considered to have low toxicity and is generally regarded as safe for use in food, pharmaceuticals, and cosmetics when used according to established standards. Its biodegradable nature and the availability of renewable raw materials for its production make it an attractive option in industries seeking more sustainable materials.

The discovery and applications of hydroxyethyl cellulose demonstrate its importance as a multifunctional polymer that has found utility in diverse industries. Its ability to modify the viscosity and texture of products, along with its mildness and versatility, makes it a key ingredient in a wide range of commercial formulations.

References

2024. Biomimetic triggered release from hydroxyethyl cellulose @ Prussian blue microparticles for tri-modality biofilm removal. Colloids and Surfaces B: Biointerfaces, 244.
DOI: 10.1016/j.colsurfb.2024.114184

2024. Cellulosic schiff base hydrogel biosensor for bacterial detection with pH/thermo-responsitivity: DFT calculations and molecular docking. International Journal of Biological Macromolecules, 280.
DOI: 10.1016/j.ijbiomac.2024.137389

2024. Development of dual drug loaded-hydrogel scaffold combining microfluidics and coaxial 3D-printing for intravitreal implantation. International Journal of Pharmaceutics, 665.
DOI: 10.1016/j.ijpharm.2024.124700