Diethylaminoethanol
[CAS# 100-37-8]

Identification

• Classification: Biochemical >> Amino acids and their derivatives >> Amino alcohol derivative
• Name: Diethylaminoethanol
• Synonyms: N,N-Diethylethanolamine; 2-Diethylaminoethanol
• Protein Sequence: G
• Molecular Formula: C₆H₁₅NO
• Molecular Weight: 117.19
• CAS Registry Number: 100-37-8
• EC Number: 202-845-2
• SMILES: CCN(CC)CCO

Properties

• Density: 0.884
• Melting point: -70 ºC
• Boiling point: 161 ºC
• Refractive index: 1.44-1.442
• Flash point: 51.5 ºC
• Water solubility: soluble

Safety Data

• Hazard Symbols: GHS02;GHS05;GHS07;GHS09 Danger
• Hazard Statements: H226-H332-H312-H302-H314
• Precautionary Statements: P210-P233-P234-P240-P241-P242-P243-P260-P261-P262-P264-P264+P265-P270-P271-P280-P301+P317-P301+P330+P331-P302+P352-P302+P361+P354-P303+P361+P353-P304+P340-P305+P354+P338-P316-P317-P319-P321-P330-P361+P364-P362+P364-P363-P370+P378-P390-P403+P233-P403+P235-P405-P406-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Flammable liquids	Flam. Liq.	3	H226
Skin corrosion	Skin Corr.	1B	H314
Acute toxicity	Acute Tox.	4	H302
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H332
Serious eye damage	Eye Dam.	1	H318
Specific target organ toxicity - single exposure	STOT SE	3	H335
Substances or mixtures corrosive to metals	Met. Corr.	1	H290
Acute toxicity	Acute Tox.	3	H331
Acute toxicity	Acute Tox.	3	H311
Skin sensitization	Skin Sens.	1	H317

• Transport Information: UN 2686

Discovory and Applicatios

Diethylaminoethanol, also known as 2-(diethylamino)ethanol, is an organic chemical compound with the molecular formula C6H15NO. It is a tertiary amine and a primary alcohol, which contributes to its reactivity and versatility in various applications. The compound is a clear, colorless liquid with a characteristic amine odor, and it has been extensively utilized in different industries due to its dual functionality as both a base and an alcohol.

The discovery of diethylaminoethanol dates back to early 20th-century research focused on developing intermediates for the chemical and pharmaceutical industries. Its structure combines a diethylamine group and a hydroxyl group, which allows it to act as a precursor in many synthetic reactions. Initially, it garnered attention for its potential as a chemical building block in organic synthesis, with subsequent investigations uncovering broader applications in medicinal chemistry and industrial processes.

In industrial applications, diethylaminoethanol plays a critical role in the production of coatings, resins, and adhesives. It is commonly used as a curing agent for epoxy resins and as a component in polyurethane foams, where it acts as a catalyst to accelerate the polymerization reaction. Its ability to enhance the stability and performance of these materials has made it indispensable in the manufacturing of coatings and foams used in automotive, construction, and consumer goods industries.

In the pharmaceutical sector, diethylaminoethanol serves as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its amine functionality makes it a suitable starting material for creating amine-based drugs, while the alcohol group enables further chemical modifications. Additionally, diethylaminoethanol has been investigated for its potential as a choline analog, with some studies exploring its cognitive-enhancing effects. While its direct use as a therapeutic agent is limited, its derivatives have found applications in neuropharmacology, particularly in the development of drugs targeting memory and cognitive function.

Diethylaminoethanol is also utilized in personal care products and cosmetics, where it functions as a pH adjuster and stabilizer. Its ability to neutralize acidic compounds while maintaining the desired consistency of formulations makes it valuable in the production of shampoos, lotions, and creams. Furthermore, its low toxicity and relatively mild chemical nature ensure its compatibility with skin and hair care products, enhancing their shelf life and performance.

The versatility of diethylaminoethanol continues to drive its demand across multiple industries. Ongoing research into its chemical properties and reactivity suggests potential new applications in the development of advanced materials, fine chemicals, and specialized pharmaceutical compounds. Its dual functional groups make it a promising candidate for future innovations in both industrial and medicinal chemistry.

References

2022. Kinetics development for controlled mono-methyl amine-ethoxylation reaction using laboratory scale autoclave experiments and process plant reactor data simulations. Chemical Papers, 77(4).
DOI: 10.1007/s11696-022-02583-5

2023. Comparison of Aminothermal and Hydrothermal Synthesis of SAPO-34: Impact of Synthesis Conditions on Catalyst Characteristics and MTO Catalytic Performance. Silicon, 16(3).
DOI: 10.1007/s12633-023-02669-z

2024. Simultaneous improvement of nanofluid stability and CO2 absorption by chitosan-grafted multi-walled carbon nanotubes dispersed in MDEA-based nanofluid. International Journal of Environmental Science and Technology, 21(11).
DOI: 10.1007/s13762-024-05858-4