Online Database of Chemicals from Around the World

Ceramides
[CAS# 100403-19-8]

List of Suppliers
Shanghai Kangxin Chemical Co., Ltd. China Inquire  
+86 (21) 6071-2573
shkangxin@shkangxin.com.cn
QQ chat
Chemical manufacturer since 2000
chemBlink standard supplier since 2007
Asia Talent Chemical Limited China Inquire  
+86 (755) 8665-5561
jeffreyxu@atchem.net
sinochemxu@hotmail.com
asiatalentchem@gmail.com
Skype Chat
QQ chat
Chemical manufacturer
chemBlink standard supplier since 2007
Jarchem Industries Inc. USA Inquire  
+1 (973) 344-0600
marketing@jarchem.com
Chemical manufacturer
chemBlink standard supplier since 2009
BOC Sciences USA Inquire  
+1 (631) 485-4226
info@bocsci.com
Chemical manufacturer
chemBlink standard supplier since 2010
Alfa Chemistry USA Inquire  
+1 (201) 478-8534
inquiry@alfa-chemistry.com
Chemical distributor since 2012
chemBlink standard supplier since 2012
Bais Chemical Technology Co., Ltd. China Inquire  
+86 (571) 8610-8202
+86 18158502261
kinghu@baischem.com
Chemical manufacturer since 2018
chemBlink standard supplier since 2019
Finetech Industry Limited China Inquire  
+86 (27) 8746-5837
+86 18971612321
sales@finetechnology-ind.com
QQ chat
Chemical manufacturer since 2009
chemBlink standard supplier since 2019
Suzhou Biosyntech Co., Ltd. China Inquire  
+86 13921151340
+86 (512) 6300-1269
sales2@biosyntech-suzhou.com
sales@biosyntech-suzhou.com
QQ chat
Chemical distributor since 2019
chemBlink standard supplier since 2020
Complete supplier list of Ceramides
Identification
Classification Organic raw materials >> Amino compound >> Amide compound
Name Ceramides
Synonyms N-(1,3,4-trihydroxyoctadecan-2-yl)octadec-9-enamide
Molecular Structure CAS # 100403-19-8, Ceramides, N-(1,3,4-trihydroxyoctadecan-2-yl)octadec-9-enamide
Molecular Formula C36H71NO4
Molecular Weight 581.95
CAS Registry Number 100403-19-8
EC Number 309-560-3
SMILES CCCCCCCCCCCCCCC(C(C(CO)NC(=O)CCCCCCCC=CCCCCCCCC)O)O
Properties
Density 0.9±0.1 g/cm3, Calc.*
Index of Refraction 1.486, Calc.*
Boiling Point 721.3±60.0 ºC (760 mmHg), Calc.*
Flash Point 390.0±32.9 ºC, Calc.*
* Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
SDS Available
up Discovory and Applicatios
Ceramides are a class of lipid molecules composed of sphingosine and a fatty acid. They were first identified in the early 1880s by Johann Ludwig Wilhelm Thudichum, a pioneer in brain chemistry who studied the composition of brain tissues. Thudichum’s work laid the foundation for understanding the role of complex lipids in biological systems. Ceramides derive their name from "cera," meaning wax, due to their wax-like properties. These molecules are fundamental components of cell membranes, particularly in the outermost layer of the skin.

In biological systems, ceramides play critical roles in maintaining the skin’s barrier function and regulating water permeability. They are present in high concentrations in the stratum corneum, the skin’s outer layer, where they help prevent transepidermal water loss. Ceramides also participate in cellular signaling, influencing processes such as cell growth, differentiation, apoptosis, and inflammation. Disruption in ceramide levels has been linked to various skin disorders, including atopic dermatitis, psoriasis, and ichthyosis.

The synthesis of ceramides occurs through several metabolic pathways. One of the most widely studied methods is the de novo synthesis pathway, which begins with the condensation of serine and palmitoyl-CoA to produce 3-ketodihydrosphingosine. This intermediate is then reduced to dihydrosphingosine, which subsequently undergoes N-acylation and desaturation to form ceramides. This pathway has been extensively explored due to its significance in both physiological processes and therapeutic applications. Researchers have also developed synthetic analogs of ceramides to study their biological functions and potential medical applications.

Ceramides are widely used in skincare and dermatology. Because of their essential role in maintaining skin hydration and integrity, they are key ingredients in moisturizers, cleansers, and barrier repair creams. Products containing ceramides help improve the skin’s moisture content, enhance its protective barrier, and alleviate symptoms of dry and damaged skin. In addition to skincare, ceramides have garnered interest in cancer research due to their involvement in apoptosis regulation. Elevated ceramide levels can induce cell death in cancerous tissues, making them potential targets for therapeutic intervention.

The significance of ceramides extends beyond dermatology. Recent studies have highlighted their involvement in metabolic disorders, including insulin resistance and cardiovascular diseases. As signaling molecules, ceramides influence pathways that impact lipid metabolism, energy homeostasis, and inflammatory responses. This multifaceted role positions ceramides as crucial targets for ongoing research in both health and disease contexts.

References

Thudichum, J L W, 1884. "A Treatise on the Chemical Constitution of the Brain." Bailliere, Tindall, and Cox.

Merrill, A H, Sullards, M C, Wang, E, Voss, K A, and Riley, R T, 2001. "Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins." Environmental Health Perspectives, 109, 283-289.

Huang, H C and Chang, T M, 2008. "Recent advances in the study of ceramides and their role in dermatology." Journal of Clinical and Aesthetic Dermatology, 1(4), 26-32.
Market Analysis Reports
List of Reports Available for Ceramides
Related Products
Cepharanthine  Cepheline  Cephradine monohydrate  CEP-32496 (hydrochloride)  (2S,3R)-Ceplignan  Ceramic materials and wares, chemicals  Ceramide  Ceramide 3  Ceramide AP  Ceramide np  Cerberic acid  Cerberic acid B  Cerberidol  Cerbinal  (+)-Cercosporin  Cerdulatinib  Cerdulatinib hydrochloride  Cerebrolysin  Cerebroside B  Cerebrosides, swine brain 


©  chemBlink. All rights reserved.  Content Disclaimer  |  About chemBlink  |  Contact