S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
[CAS# 132335-47-8]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Thiophene compound
• Name: S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
• Synonyms: S-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate; (S)-N,N-Dimethyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine ethanedioate (1:1)
• Molecular Formula: C₁₉H₂₁NOS^.C₂H₂O₄
• Molecular Weight: 401.48
• CAS Registry Number: 132335-47-8
• EC Number: 603-567-8
• SMILES: CN(C)CC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.C(=O)(C(=O)O)O

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Reproductive toxicity	Repr.	2	H361
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2A	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovory and Applicatios

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate, often abbreviated as S-(+)-NAP, was discovered through rigorous chemical synthesis and screening processes. Developed by pharmaceutical researchers, its synthesis involved intricate steps to achieve the desired stereochemistry, resulting in a potent and selective compound.

S-(+)-NAP exhibits promising potential in the treatment of neurological disorders, particularly Parkinson's disease. It acts as a selective agonist of dopamine receptors, effectively modulating dopamine levels in the brain. This mechanism offers neuroprotective effects, potentially slowing down the progression of Parkinson's and mitigating its symptoms.

Researchers are exploring the antidepressant properties of S-(+)-NAP due to its ability to enhance serotonin and norepinephrine neurotransmission. By regulating the levels of these neurotransmitters, S-(+)-NAP may offer a novel approach to managing depression and related mood disorders.

Preliminary studies suggest that S-(+)-NAP could aid in the management of drug addiction by targeting the brain's reward system. Its action on specific neurotransmitter pathways holds promise in reducing cravings and withdrawal symptoms associated with substance abuse disorders.

Neuropathic pain, a debilitating condition resulting from nerve damage, poses significant therapeutic challenges. S-(+)-NAP's modulation of neurotransmitter activity offers a potential avenue for alleviating neuropathic pain, improving patients' quality of life.

Traumatic brain injury often leads to long-term neurological deficits due to secondary injury mechanisms. S-(+)-NAP's neuroprotective properties, including anti-inflammatory and antioxidant effects, present a promising strategy for mitigating damage following TBI and promoting recovery.

Early research indicates that S-(+)-NAP may hold therapeutic potential in Alzheimer's disease by targeting amyloid-beta aggregation and neuroinflammation, key pathological processes in the disease's progression.