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2,3-Dihydrobenzo[b]furan-7-ylamine
[CAS# 13414-56-7]

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Identification
Classification Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Amine
Name 2,3-Dihydrobenzo[b]furan-7-ylamine
Molecular Structure CAS # 13414-56-7, 2,3-Dihydrobenzo[b]furan-7-ylamine
Molecular Formula C8H9NO
Molecular Weight 135.16
CAS Registry Number 13414-56-7
EC Number 691-234-8
SMILES C1COC2=C1C=CC=C2N
Properties
Density 1.2±0.1 g/cm3, Calc.*
Index of Refraction 1.627, Calc.*
Boiling Point 271.1±29.0 ºC (760 mmHg), Calc.*
Flash Point 136.6±17.5 ºC, Calc.*
* Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbols symbol   GHS07 Warning    Details
Hazard Statements H302-H315-H319-H335    Details
Precautionary Statements P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P319-P321-P330-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501    Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Skin irritationSkin Irrit.2H315
Specific target organ toxicity - single exposureSTOT SE3H335
Acute toxicityAcute Tox.4H302
Eye irritationEye Irrit.2AH319
Eye irritationEye Irrit.2H319
SDS Available
up Discovory and Applicatios
2,3-Dihydrobenzo[b]furan-7-ylamine is an organic compound that belongs to the class of heterocyclic amines. It features a benzo[b]furan core structure, which consists of a fused benzene ring and a furan ring. The structure of 2,3-dihydrobenzo[b]furan-7-ylamine includes an amine group (-NH2) at the 7-position of the fused ring system. The presence of both the furan ring and the amine functional group gives this compound its distinct chemical properties and makes it a valuable building block in organic synthesis.

The discovery of 2,3-dihydrobenzo[b]furan-7-ylamine is part of the larger exploration of heterocyclic compounds, which have proven to be important in the development of new materials, pharmaceuticals, and agrochemicals. Compounds containing fused heterocyclic systems, such as the benzo[b]furan structure, have garnered significant interest due to their potential biological activities, which include antimicrobial, anticancer, and anti-inflammatory effects.

In terms of applications, 2,3-dihydrobenzo[b]furan-7-ylamine serves as a key intermediate in organic synthesis. Its ability to undergo various chemical transformations makes it a versatile building block in the development of more complex molecules. One of the primary applications of this compound lies in the pharmaceutical industry, where it is used as a precursor for the synthesis of bioactive molecules. The amine group on the molecule is an important functional group that can participate in a range of reactions, including nucleophilic substitution and condensation reactions, allowing for the creation of compounds with diverse pharmacological properties.

In drug discovery, 2,3-dihydrobenzo[b]furan-7-ylamine has been explored for its potential in the development of new therapeutic agents. The presence of the furan ring system contributes to the compound's ability to interact with biological targets, making it useful in the design of molecules with specific biological activities. Researchers have investigated the use of derivatives of this compound in the treatment of various diseases, such as cancer and neurological disorders. The versatility of the amine group allows for easy modification, enabling the creation of novel compounds with improved bioactivity and selectivity for specific targets.

Moreover, 2,3-dihydrobenzo[b]furan-7-ylamine is also used in materials science and chemical research. Its unique structure makes it a potential candidate for the development of new functional materials, such as organic semiconductors, light-emitting devices, and sensors. The ability of the furan ring to participate in electron transfer reactions opens up possibilities for the compound to be used in electronic and optoelectronic applications.

Additionally, the compound's role in medicinal chemistry extends beyond its use as a direct drug candidate. It can be employed as a scaffold in combinatorial chemistry, where libraries of compounds are synthesized to explore structure-activity relationships and identify promising leads for further development. This approach has led to the discovery of new classes of molecules with enhanced activity and specificity.

In conclusion, 2,3-dihydrobenzo[b]furan-7-ylamine is a valuable compound in the fields of organic synthesis, drug discovery, and materials science. Its unique structure and reactivity make it an important intermediate in the development of new drugs and functional materials. The compound's potential therapeutic applications, combined with its versatility in chemical reactions, highlight its importance in modern chemical research.
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