Tiletamine hydrochloride
[CAS# 14176-50-2]

Identification

• Classification: API >> Nervous system medication
• Name: Tiletamine hydrochloride
• Synonyms: 2-(Ethylamino)-2-(2-thienyl)cyclohexanone hydrochloride
• Molecular Formula: C₁₂H₁₇NOS^.HCl
• Molecular Weight: 259.79
• CAS Registry Number: 14176-50-2
• EC Number: 604-248-6
• SMILES: CCNC1(CCCCC1=O)C2=CC=CS2.Cl

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H336
• Precautionary Statements: P261-P271-P304+P340+P312-P403+P233-P405-P501

Discovory and Applicatios

Tiletamine hydrochloride, a dissociative anesthetic and tranquilizer, was first synthesized in the 1960s by a team of pharmaceutical researchers. Initially developed as an anesthetic agent for veterinary use, its discovery emerged from efforts to create safer and more effective alternatives to existing anesthetics. Tiletamine's unique pharmacological profile, characterized by rapid onset, potent analgesia, and minimal cardiorespiratory depression.

Tiletamine hydrochloride, often combined with zolazepam to form the anesthetic drug Telazol�, is widely used in veterinary medicine for anesthesia and immobilization of animals. Its rapid onset and reliable sedative effects make it suitable for various procedures.

Tiletamine hydrochloride plays a crucial role in wildlife conservation efforts, particularly in the immobilization and transportation of wild animals for research, relocation, and rehabilitation purposes.

Tiletamine hydrochloride finds applications in veterinary emergency medicine for the rapid induction of anesthesia in critically ill or injured animals. Its ability to induce deep sedation and analgesia enables veterinary practitioners to perform urgent procedures, such as wound treatment, fracture stabilization, and diagnostic interventions.

Zoological institutions utilize tiletamine hydrochloride in the anesthesia and immobilization of captive animals for routine health assessments, veterinary procedures, and behavioral studies. Its predictable effects and reversible action allow for safe handling and medical care of zoo animals.

Tiletamine hydrochloride serves as a valuable tool in biomedical research for studying anesthesia, analgesia, and animal physiology. Researchers utilize tiletamine-based anesthetic protocols to investigate neurological function, pain mechanisms, and pharmacological interventions in preclinical models.

References

2023. Assessment of a Combination of Tiletamine/Zolazepam, Ketamine, and Dexmedetomidine for Anesthesia of Swine (Sus domesticus). Journal of the American Association for Laboratory Animal Science : JAALAS, 62(5).
DOI: 10.30802/aalas-jaalas-22-000083

2023. EVALUATION OF A COMBINATION OF TILETAMINE-ZOLAZEPAM, MEDETOMIDINE, AND AZAPERONE WITH NASAL OXYGEN SUPPLEMENTATION FOR THE IMMOBILIZATION OF CAPTIVE CHACOAN PECCARIES (CATAGONUS WAGNERI) IN THE CHACO REGION OF PARAGUAY. Journal of Wildlife Diseases, 59(2).
DOI: 10.7589/jwd-d-21-00203

1975. Absence of Sensitization to Epinephrine-Induced Cardiac Arrhythmia and Fibrillation in Dogs and Cats Anesthetized with CI 744. American Journal of Veterinary Research, 36(5).
DOI: 10.2460/ajvr.1975.36.05.695