Minodronic acid
[CAS# 155648-60-5]

Identification

• Classification: Organic raw materials >> Organic phosphine compound
• Name: Minodronic acid
• Synonyms: P,P'-(1-Hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bisphosphonic acid hydrate
• Molecular Formula: C₉H₁₂N₂O₇P₂^.H₂O
• Molecular Weight: 340.17
• CAS Registry Number: 155648-60-5
• EC Number: 696-656-6
• SMILES: C1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O.O

Safety Data

• Hazard Symbols: GHS06;GHS08 Danger
• Hazard Statements: H301-H361
• Precautionary Statements: P203-P264-P270-P280-P301+P316-P318-P321-P330-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	3	H301
Reproductive toxicity	Repr.	2	H361

Discovory and Applicatios

Minodronic acid is a synthetic bisphosphonate compound that plays a significant role in the treatment of bone-related disorders. It is a member of the bisphosphonate class of drugs, which are primarily used to treat conditions that involve excessive bone resorption, such as osteoporosis, Paget’s disease of bone, and metastatic bone disease. Minodronic acid was developed as a more potent alternative to other bisphosphonates, offering enhanced activity in inhibiting osteoclast-mediated bone resorption.

The discovery of minodronic acid is part of the ongoing efforts to improve the efficacy and safety profiles of bisphosphonates, which have been in clinical use since the 1970s. Bisphosphonates work by inhibiting the activity of osteoclasts, the cells responsible for breaking down bone tissue, thereby reducing the rate of bone loss. Minodronic acid, with its unique chemical structure, was designed to possess stronger binding affinity to bone mineral than other bisphosphonates, leading to longer-lasting effects and improved therapeutic outcomes.

Minodronic acid is used to treat conditions such as osteoporosis, where bone density decreases, and the risk of fractures increases, particularly in postmenopausal women and elderly patients. It is also used to manage Paget’s disease, a condition characterized by abnormal bone remodeling, and to prevent bone complications in patients with metastatic cancer involving the bones. The drug works by binding to hydroxyapatite in bone, where it inhibits osteoclast activity, reducing bone resorption and helping to maintain or increase bone mass. In addition, minodronic acid is useful in conditions involving hypercalcemia of malignancy, where excessive calcium is released from bones due to cancerous growth.

In clinical settings, minodronic acid is administered as an intravenous infusion, typically in a hospital or outpatient clinic, depending on the condition being treated. The drug is usually administered in a cyclical regimen, with treatment intervals depending on the severity of the condition and patient response. Its effectiveness has been shown in clinical trials, where it has been found to significantly increase bone mineral density and reduce the risk of fractures in patients with osteoporosis.

Minodronic acid has also been explored for its potential in other applications beyond osteoporosis and cancer-related bone diseases. Research into its impact on the prevention of bone fractures following orthopedic surgery or in individuals with severe bone loss continues. Furthermore, there are ongoing studies aimed at understanding the broader anti-inflammatory effects of bisphosphonates like minodronic acid, as they may play a role in managing other inflammatory diseases.

Despite its efficacy, the use of minodronic acid and other bisphosphonates is not without side effects. Common adverse effects include gastrointestinal issues, such as nausea and abdominal pain, as well as potential musculoskeletal pain. Long-term use of bisphosphonates, including minodronic acid, may also be associated with rare but serious side effects like osteonecrosis of the jaw (ONJ) and atypical femoral fractures. Consequently, patients receiving bisphosphonates require careful monitoring, and treatment regimens are often tailored to minimize risks.

In conclusion, minodronic acid is an important advancement in the treatment of bone diseases, providing an effective option for reducing bone loss and the risk of fractures in patients with conditions like osteoporosis and metastatic bone disease. Its development and continued research highlight the ongoing progress in improving therapies for bone health and related disorders.