Sodium acetylated hyaluronate
[CAS# 158254-23-0]

Identification

• Name: Sodium acetylated hyaluronate
• CAS Registry Number: 158254-23-0

Discovory and Applicatios

Sodium acetylated hyaluronate is a modified form of hyaluronic acid (HA) that has become a major advancement in dermatology and biomedical applications. This compound is known for its superior properties compared to standard hyaluronic acid, providing improved moisture retention and skin barrier protection, making it highly valued in skin care and medical treatments.

Hyaluronic acid, a polysaccharide found naturally in the human body, primarily in connective tissue, skin, and eyes, has long been lauded for its exceptional water-retaining abilities. This property makes it a key ingredient in maintaining skin moisture and elasticity. However, the discovery of sodium acetylated hyaluronate was designed to enhance HA's already exceptional properties. By acetyling hyaluronic acid, scientists introduced an acetyl group into its molecular structure, which improves its stability and moisture retention abilities.

Acetylation of hyaluronic acid produces sodium acetylated hyaluronate, a substance that is more effective at retaining moisture for longer periods of time. This modification enhances the compound's ability to adhere to the skin, providing sustained moisturizing benefits. As a result, sodium acetylated hyaluronate has become a popular ingredient in advanced skin care formulations. Its superior moisturizing properties help improve skin texture, reduce dryness, and maintain a youthful appearance. Additionally, it is able to enhance skin barrier function, which can help treat conditions where the skin's protective barrier is compromised, such as eczema and dermatitis.

In addition to its widespread use in skin care, sodium acetylated hyaluronate is also used in medical applications. Its enhanced moisturizing properties and biocompatibility make it an excellent choice for wound healing treatments. By maintaining a moist environment, it supports the natural healing process, reduces scarring, and accelerates tissue regeneration. This makes it particularly useful in postoperative care and treating chronic wounds, such as diabetic ulcers.

In addition, sodium acetylated hyaluronate is used in ophthalmology. Due to its viscoelastic properties, it is an essential ingredient in eye drops and ophthalmic solutions for the treatment of dry eyes and other ocular surface diseases. It provides long-lasting lubrication and protection to the ocular surface, enhancing patient comfort and alleviating symptoms associated with dry eyes.

The versatility of sodium acetylated hyaluronate extends to its use in joint health. Intra-articular injections of this compound can be used to treat osteoarthritis, improve joint lubrication, and relieve pain. Its ability to enhance the viscoelastic properties of synovial fluid helps cushion and protect joints, thereby improving mobility and quality of life for patients with joint disorders.

Despite its numerous benefits, the use of sodium hyaluronate, like any other compound, requires careful consideration. While it is generally well tolerated, ensuring that the formulation is correct and safety standards are adhered to is critical to avoiding potential side effects and ensuring optimal efficacy.

References

Papakonstantinou, E., Roth, M. and Karakiulakis, G., 2012. Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, Volume 4, Issue 3, pp. 253-258.

Gupta, R.C., Lall, R., Srivastava, A. and Sinha, A., 2019. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Frontiers in Veterinary Science, Volume 6, Article 192.

Stern, R. and Jedrzejas, M.J., 2006. Hyaluronidases: Their genomics, structures, and mechanisms of action. Chemical Reviews, Volume 106, Issue 3, pp. 818-839.