5-(1E )-1-Propen-1-yl-1H -Pyrazol-3-amine
[CAS# 1609119-58-5]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Amine
• Name: 5-(1E )-1-Propen-1-yl-1H -Pyrazol-3-amine
• Synonyms: 5-prop-1-enyl-1H-pyrazol-3-amine
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• CAS Registry Number: 1609119-58-5
• SMILES: CC=CC1=CC(=NN1)N

Properties

• Solubility: Slightly Soluble (1.8 g/L) (25 ºC), Calc.^*
• Density: 1.181±0.06 g/cm³ (20 ºC 760 Torr), Calc.^*
• Boiling point: 362.6±30.0 ºC (760 Torr), Calc.^*
• Flash point: 200.6±11.8 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2021 ACD/Labs)

Discovory and Applicatios

5-(1E)-1-Propen-1-yl-1H-pyrazol-3-amine is a chemical compound with a structure featuring a pyrazole ring, which is a five-membered aromatic ring containing three carbon atoms and two nitrogen atoms. The propenyl group attached at the 5-position of the pyrazole ring contributes to the compound’s reactivity and offers versatility for further chemical modifications. This compound has attracted interest due to its potential applications in various fields, including medicinal chemistry and material science.

The discovery of 5-(1E)-1-propen-1-yl-1H-pyrazol-3-amine is part of ongoing research focused on pyrazole derivatives, which are known for their diverse biological activities. Pyrazoles and their derivatives have been extensively studied for their potential as therapeutic agents, particularly due to their ability to interact with enzymes and receptors involved in various biological processes. The presence of the propenyl group on the pyrazole ring may enhance the molecule’s ability to interact with biological targets, making it an interesting candidate for drug development.

In terms of medicinal applications, 5-(1E)-1-propen-1-yl-1H-pyrazol-3-amine has shown promise in early-stage research for its potential antimicrobial and anti-inflammatory properties. The pyrazole ring system is often associated with compounds that exhibit activity against a range of pathogens, including bacteria, fungi, and viruses. The introduction of the propenyl group may influence the compound’s pharmacokinetic properties, such as solubility, permeability, and metabolic stability, which are critical for developing effective therapeutic agents.

Additionally, the compound’s structure makes it a useful building block in the synthesis of other pyrazole-based derivatives. Researchers are exploring the synthesis of novel compounds that incorporate 5-(1E)-1-propen-1-yl-1H-pyrazol-3-amine as a key intermediate. These derivatives may exhibit enhanced bioactivity, such as improved potency or selectivity against specific targets, making them valuable in drug design.

Apart from medicinal chemistry, 5-(1E)-1-propen-1-yl-1H-pyrazol-3-amine could have applications in material science. The ability of pyrazole derivatives to form coordination complexes with metal ions opens the door for potential use in the development of sensors, catalysts, and other advanced materials. Its reactivity, particularly in the presence of transition metals, may make it useful in the synthesis of novel materials with specialized electronic or optical properties.

The versatility of 5-(1E)-1-propen-1-yl-1H-pyrazol-3-amine in both biological and material science applications makes it a compound of interest for future research. Further studies are needed to fully understand its biological mechanisms and potential therapeutic uses. As research continues, this compound could play a key role in the development of new drugs and materials with a wide range of applications.