Lapaquistat acetate
[CAS# 189060-13-7]

Identification

• Name: Lapaquistat acetate
• Synonyms: 1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid; TAK 475
• Molecular Formula: C₃₃H₄₁ClN₂O₉
• Molecular Weight: 645.14
• CAS Registry Number: 189060-13-7
• EC Number: 961-990-6

Properties

• Solubility: Practically insoluble (0.014 g/L) (25 ºC), Calc.^*
• Density: 1.246±0.06 g/cm³ (20 ºC 760 Torr), Calc.^*
• Melting point: 194-196 ºC^**

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2014 ACD/Labs)

^** Miki, Takashi; Journal of Medicinal Chemistry 2002, V45(20), P4571-4580.

Safety Data

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2A	H319
Acute toxicity	Acute Tox.	4	H302
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335