3-(Trifluoromethyl)pyrazole
[CAS# 20154-03-4]

Identification

• Classification: Organic raw materials >> Organic fluorine compound
• Name: 3-(Trifluoromethyl)pyrazole
• Synonyms: 3-(Trifluoromethyl)-1H-pyrazole
• Molecular Formula: C₄H₃F₃N₂
• Molecular Weight: 136.08
• CAS Registry Number: 20154-03-4
• EC Number: 628-556-5
• SMILES: C1=C(NN=C1)C(F)(F)F

Properties

• Density: 1.4±0.1 g/cm³, Calc.^*
• Melting point: 45-47 ºC, (expl.)
• Index of Refraction: 1.417, Calc.^*
• Boiling Point: 177.7±35.0 ºC (760 mmHg), Calc.^*, 70 ºC (2 mmHg) (expl.)
• Flash Point: 61.3±25.9 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H315-H319-H335
• Precautionary Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovory and Applicatios

3-(Trifluoromethyl)pyrazole is a fluorinated heterocyclic compound that combines a pyrazole ring with a trifluoromethyl group (-CF3) at the 3-position of the ring. This compound has gained attention for its unique chemical properties, particularly the enhanced stability and reactivity imparted by the trifluoromethyl group. Fluorinated compounds like 3-(trifluoromethyl)pyrazole are known for their ability to increase lipophilicity, metabolic stability, and bioactivity, making them valuable in fields such as medicinal chemistry, agrochemicals, and materials science.

The compound’s discovery is rooted in the exploration of pyrazole derivatives and their potential applications in drug development and agricultural chemistry. The trifluoromethyl group is recognized for its ability to modulate the electronic properties of the pyrazole ring, improving its reactivity and selectivity. This makes 3-(trifluoromethyl)pyrazole an attractive building block for the design of bioactive molecules.

In medicinal chemistry, 3-(trifluoromethyl)pyrazole has shown promise as a precursor for compounds targeting neurotransmitter systems, especially in the treatment of neurological disorders. The addition of the trifluoromethyl group increases the compound's lipophilicity, enhancing its ability to penetrate biological membranes and interact with enzymes or receptors. This modification also improves the metabolic stability of the molecule, potentially extending its half-life and bioavailability. Compounds derived from 3-(trifluoromethyl)pyrazole have been explored for their effects on the GABAergic and glutamatergic systems, which play crucial roles in mood regulation, cognition, and anxiety.

Beyond its medicinal uses, 3-(trifluoromethyl)pyrazole is valuable in the agrochemical industry. Fluorinated pyrazoles are often incorporated into pesticides, herbicides, and fungicides to enhance their stability, selectivity, and effectiveness. The trifluoromethyl group improves the compound’s environmental persistence and reduces its volatility, making it an ideal candidate for the development of agrochemicals with minimal environmental impact. For instance, pyrazole-based fungicides have been formulated using the trifluoromethyl group to improve their affinity for fungal enzymes, thereby increasing their potency and selectivity.

In addition to its pharmaceutical and agricultural applications, 3-(trifluoromethyl)pyrazole plays a role in materials science. It is used in the development of organic semiconductors, particularly in the fabrication of organic light-emitting diodes (OLEDs). The trifluoromethyl group enhances the electron-withdrawing properties of the molecule, making it suitable for use as an electron transport material in electronic devices.

The synthetic routes to 3-(trifluoromethyl)pyrazole typically involve reactions of pyrazole with trifluoromethylating agents, such as trifluoromethyl iodide or trifluoromethyl sulfonates. These methods allow for the easy incorporation of the trifluoromethyl group into pyrazole-based structures, facilitating the production of a wide range of derivatives for various applications.

Despite its promising applications, further research is needed to fully explore the biological and chemical properties of 3-(trifluoromethyl)pyrazole. Optimization of its solubility, pharmacokinetics, and target specificity will be key for the success of trifluoromethylpyrazole-based compounds in drug development and agrochemical formulation.

In conclusion, 3-(trifluoromethyl)pyrazole is a versatile compound with significant potential in medicinal chemistry, agrochemicals, and materials science. Its unique combination of stability, reactivity, and bioactivity makes it an important building block in the development of novel therapeutic agents, pesticides, and electronic materials.

References

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