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5-(4-Bromophenyl)-2-pyrrolidinone
[CAS# 207989-90-0]

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Identification
Classification Organic raw materials >> Heterocyclic compound >> Pyrroles
Name 5-(4-Bromophenyl)-2-pyrrolidinone
Molecular Structure CAS # 207989-90-0, 5-(4-Bromophenyl)-2-pyrrolidinone
Molecular Formula C10H10BrNO
Molecular Weight 240.10
CAS Registry Number 207989-90-0
EC Number 860-470-5
SMILES C1CC(=O)NC1C2=CC=C(C=C2)Br
Properties
Solubility Very slightly soluble (0.5 g/L) (25 ºC), Calc.*
Density 1.5±0.1 g/cm3, Calc.*
Index of Refraction 1.584, Calc.*
Boiling Point 407.0±45.0 ºC (760 mmHg), Calc.*
Flash Point 200.0±28.7 ºC, Calc.*
* Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbols symbol   GHS07 Warning    Details
Hazard Statements H315-H319-H335    Details
Precautionary Statements P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501    Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Eye irritationEye Irrit.2AH319
Specific target organ toxicity - single exposureSTOT SE3H335
Skin irritationSkin Irrit.2H315
SDS Available
up Discovory and Applicatios
5-(4-Bromophenyl)-2-pyrrolidinone is a chemical compound that belongs to the class of pyrrolidinone derivatives, which are characterized by their versatile biological activities and usefulness in synthetic chemistry. The molecule consists of a pyrrolidinone ring, a key feature in many pharmacologically active substances, and a 4-bromophenyl group attached to the 5-position of the ring. This combination of a heterocyclic structure and a halogenated aromatic group has made 5-(4-bromophenyl)-2-pyrrolidinone a molecule of interest in the field of medicinal chemistry and organic synthesis.

The discovery of 5-(4-bromophenyl)-2-pyrrolidinone is likely rooted in the exploration of pyrrolidinone derivatives, which have been known for their broad range of biological activities. Pyrrolidinone-based compounds have been investigated for their neuroactive, anti-inflammatory, and anticancer properties, which make them valuable in drug development. The introduction of a bromine atom at the para-position of the phenyl ring further enhances the molecule's ability to participate in various chemical reactions, such as electrophilic substitution or cross-coupling reactions, which are useful in the development of more complex molecules.

In the pharmaceutical field, 5-(4-bromophenyl)-2-pyrrolidinone has the potential for use as an intermediate in the synthesis of bioactive compounds. Its structural features, which include a nitrogen-containing heterocyclic ring and a halogenated aromatic group, suggest that it may be employed in the design of molecules aimed at targeting specific enzymes or receptors involved in cellular signaling pathways. Additionally, the pyrrolidinone ring system is often associated with compounds that can influence central nervous system activity, which could make 5-(4-bromophenyl)-2-pyrrolidinone a candidate for neuroactive drug development.

Beyond its use in drug discovery, the compound could also find applications in materials science and chemical synthesis. Pyrrolidinone derivatives are frequently used as building blocks in the construction of polymers, fine chemicals, and specialty compounds. The halogenated phenyl group might make 5-(4-bromophenyl)-2-pyrrolidinone useful in the development of materials with specific electrical or optical properties. Furthermore, the compound could play a role in the synthesis of complex molecules through reactions such as Suzuki or Heck coupling, where the bromine atom serves as a functional group for efficient cross-coupling reactions.

In summary, 5-(4-bromophenyl)-2-pyrrolidinone is a promising compound with applications in both medicinal chemistry and materials science. Its structure provides a basis for further research into its biological activity, as well as its potential role in the development of new materials and synthetic methodologies. As research in this area progresses, this compound could become an important intermediate in the synthesis of novel therapeutic agents and materials.
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