Afatinib Impurity E
[CAS# 2223677-63-0]

Identification

• Name: Afatinib Impurity E
• Synonyms: (E)-N-[4-(3,4-dichloroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
• Molecular Formula: C₂₄H₂₅Cl₂N₅O₃
• Molecular Weight: 502.39
• CAS Registry Number: 2223677-63-0
• SMILES: CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)Cl)Cl)O[C@H]4CCOC4

Properties

• Density: 1.4±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.681, Calc.^*
• Boiling Point: 696.2±55.0 ºC (760 mmHg), Calc.^*
• Flash Point: 374.8±31.5 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.