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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
[CAS# 23007-85-4]

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Complete supplier list of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Identification
Classification Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyridine compound
Name 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Synonyms 23007-85-4
Molecular Structure CAS # 23007-85-4, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, 23007-85-4
Molecular Formula C12H15N.HCl
Molecular Weight 209.71
CAS Registry Number 23007-85-4
EC Number 622-416-7
SMILES CN1CCC(=CC1)C2=CC=CC=C2.Cl
Properties
Solubility Water: ~ 100 mM (Expl.)
Safety Data
Hazard Symbols symbol symbol   GHS06;GHS07 Danger    Details
Hazard Statements H301-H301-H311-H315-H319-H331-H335    Details
Precautionary Statements P261-P262-P264-P264+P265-P270-P271-P280-P301+P316-P302+P352-P304+P340-P305+P351+P338-P316-P319-P321-P330-P332+P317-P337+P317-P361+P364-P362+P364-P403+P233-P405-P501    Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Acute toxicityAcute Tox.3H301
Acute toxicityAcute Tox.3H331
Eye irritationEye Irrit.2H319
Skin irritationSkin Irrit.2H315
Specific target organ toxicity - single exposureSTOT SE3H335
Acute toxicityAcute Tox.3H311
Specific target organ toxicity - single exposureSTOT SE1H370
Transport Information UN 2811
SDS Available
up Discovory and Applicatios
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a chemical compound that has been extensively studied for its role in neuroscience research, particularly in modeling Parkinson’s disease. The compound was discovered during investigations into neurotoxins that induce selective degeneration of dopaminergic neurons in the brain, mimicking the pathology observed in Parkinson’s disease.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is known as MPTP hydrochloride and functions as a neurotoxin. When administered to certain animals, including primates and rodents, MPTP crosses the blood-brain barrier and is metabolized by monoamine oxidase B (MAO-B) in glial cells to produce 1-methyl-4-phenylpyridinium ion (MPP+), a toxic metabolite. MPP+ selectively accumulates in dopaminergic neurons of the substantia nigra pars compacta via dopamine transporters. This accumulation causes mitochondrial dysfunction and oxidative stress, leading to the degeneration of these neurons.

The neurotoxic properties of MPTP hydrochloride have made it a valuable tool for generating animal models of Parkinson’s disease, which are critical for studying the disease’s pathophysiology and for testing potential therapeutic interventions. MPTP-induced models replicate many features of Parkinson’s disease, including motor symptoms such as bradykinesia, rigidity, and tremor, as well as the characteristic loss of dopaminergic neurons and dopamine depletion in the striatum.

Beyond its role in disease modeling, research on MPTP hydrochloride has contributed significantly to the understanding of neurodegeneration mechanisms, mitochondrial impairment, and the involvement of oxidative stress in neuronal death. It has also spurred the development of neuroprotective strategies and pharmacological agents aimed at preventing or slowing the progression of Parkinson’s disease.

In laboratory settings, MPTP hydrochloride is typically used in controlled doses to induce dopaminergic neurodegeneration in animal studies. Its use requires careful handling due to its neurotoxic nature and potential risks to researchers. The compound has not been developed as a therapeutic agent but remains indispensable for experimental research into neurodegenerative disorders.

Overall, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a critical compound in neuroscience that enables the study of Parkinson’s disease mechanisms and the evaluation of potential treatments through reliable animal models.

References

1986. Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues. Journal of Medicinal Chemistry, 29(3).
DOI: 10.1021/jm00153a019

2023. Gut Microbial Alteration in MPTP Mouse Model of Parkinson Disease is Administration Regimen Dependent. Cellular and Molecular Neurobiology, 43(5).
DOI: 10.1007/s10571-023-01319-7

2024. Positive allosteric mGluR2 modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset. Naunyn-Schmiedeberg's Archives of Pharmacology, 397(12).
DOI: 10.1007/s00210-024-03215-3
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