epsilon-Polylysin
[CAS# 28211-04-3]

Identification

• Classification: Biochemical >> Amino acids and their derivatives >> Lysine derivative
• Name: epsilon-Polylysin
• Synonyms: Poly[imino[(2S)-2-amino-1-oxo-1,6-hexanediyl]]
• Protein Sequence: X
• Molecular Formula: (C₆H₁₂N₂O)_n
• CAS Registry Number: 28211-04-3
• EC Number: 825-244-2
• SMILES: CCCCC[C@@H](C(=O)NC)N

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Discovory and Applicatios

Epsilon-polylysine, often abbreviated as ε-polylysine, is a biopolymer notable for its applications in food preservation and medicine. It is a cyclic, cationic peptide composed of multiple lysine units linked through amide bonds, forming a ring structure. The discovery and development of ε-polylysine highlight its significance in various fields due to its antimicrobial properties and biocompatibility.

The discovery of ε-polylysine dates back to the 1970s when researchers began to investigate natural antimicrobial peptides and their potential applications. It was first isolated from the bacterium *Streptomyces albulus*, a known producer of various biologically active compounds. The unique cyclic structure of ε-polylysine, with its alternating lysine residues, was identified as a key factor contributing to its antimicrobial activity. This peptide's ability to inhibit the growth of a wide range of microorganisms made it a subject of interest for food preservation and other uses.

In the food industry, ε-polylysine is used as a natural preservative. Its antimicrobial properties enable it to inhibit the growth of bacteria, molds, and yeasts, extending the shelf life of various food products. It is particularly effective in preventing spoilage in products like baked goods, processed meats, and dairy products. ε-Polylysine's natural origin and effectiveness make it a desirable alternative to synthetic preservatives, aligning with the growing consumer demand for natural and safe food additives.

Apart from its role in food preservation, ε-polylysine is also employed in medical and pharmaceutical applications. Its biocompatibility and antimicrobial properties make it useful in the development of antimicrobial coatings and wound dressings. ε-Polylysine-based materials can be used to create surfaces that resist microbial contamination, reducing the risk of infections in medical settings. Additionally, its potential use in drug delivery systems is being explored, where ε-polylysine can act as a carrier for various therapeutic agents.

In agriculture, ε-polylysine is investigated for its potential as a natural biopesticide. Its ability to inhibit fungal growth makes it a candidate for controlling plant pathogens and extending the shelf life of harvested crops. Research into ε-polylysine's effectiveness in this area could provide environmentally friendly alternatives to synthetic pesticides, promoting sustainable agricultural practices.

The biocompatibility and antimicrobial properties of ε-polylysine make it a versatile compound with applications across multiple industries. Its role in food preservation, medical applications, and agriculture underscores its significance as a natural and effective antimicrobial agent. Ongoing research and development continue to explore new applications and optimize the use of ε-polylysine in various fields.

In conclusion, ε-polylysine is a biopolymer with diverse applications due to its antimicrobial properties and biocompatibility. Its discovery and development have led to significant advancements in food preservation, medical materials, and agricultural practices, highlighting its importance as a versatile and effective chemical substance.