PMK ethyl glycidate
[CAS# 28578-16-7]

Identification

• Classification: Organic raw materials >> Carboxylic compounds and derivatives >> Carboxylic esters and their derivatives
• Name: PMK ethyl glycidate
• Synonyms: PMK oil; Ethyl 3-(1,3-benzodioxol-5-yl)-2-methyloxirane-2-carboxylate
• Molecular Formula: C₁₃H₁₄O₅
• Molecular Weight: 250.25
• CAS Registry Number: 28578-16-7
• SMILES: CCOC(=O)C1(C(O1)C2=CC3=C(C=C2)OCO3)C

Properties

• Solubility: 870.7 mg/L (25 ºC water)
• Density: 1.3±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.554, Calc.^*
• Melting point: 108.74 ºC
• Boiling Point: 330.84 ºC, 327.8±42.0 ºC (760 mmHg), Calc.^*
• Flash Point: 143.0±27.9 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS02;GHS07 Danger
• Hazard Statements: H225-H302-H312-H319-H332
• Precautionary Statements: P210-P261-P264-P280-P337+P313-P301+P312-P302+P352-P303+P361+P353-P304+P340-P305+P351+P351-P321-P330-P362+P364

Discovory and Applicatios

PMK ethyl glycidate, also known as ethyl 3-(phenylmethoxy)-2-oxiranecarboxylate, is a synthetic chemical compound first identified in the early 21st century as part of research into precursors for pharmaceutical and psychoactive substances. Its discovery was largely driven by the need for alternative synthesis routes to produce key intermediates in the manufacture of MDMA (3,4-methylenedioxy-methamphetamine). Researchers focused on developing efficient methods to convert safrole or isosafrole into PMK (piperonyl methyl ketone) derivatives, leading to the synthesis of PMK ethyl glycidate.

PMK ethyl glycidate is primarily used as an intermediate in the synthesis of various pharmaceutical compounds. Its role in the production of MDMA is well-documented, but beyond illicit drug manufacture, it is also valuable in the development of legitimate pharmaceuticals. The compound's ability to undergo various chemical reactions makes it a versatile building block for synthesizing complex molecules used in medication production.

In chemical research, PMK ethyl glycidate serves as a model compound for studying reaction mechanisms and developing new synthetic methodologies. Its unique structure, which includes both epoxide and ester functional groups, allows researchers to explore a variety of chemical transformations. Studies involving PMK ethyl glycidate contribute to advancements in organic synthesis, aiding in the discovery of new reactions and the improvement of existing processes.

PMK ethyl glycidate finds applications in industrial chemistry as a precursor for producing fine chemicals and specialty chemicals. Its synthesis involves relatively straightforward steps, making it a cost-effective and efficient starting material for manufacturing a range of chemical products. Industries that rely on complex organic synthesis utilize PMK ethyl glycidate to streamline production processes and reduce costs.

In analytical chemistry, PMK ethyl glycidate is used as a reference standard for detecting and quantifying related compounds in various samples. Laboratories involved in forensic analysis, quality control, and regulatory compliance employ this compound to ensure the accuracy and reliability of their measurements. Its well-defined chemical properties make it an ideal standard for calibration and validation purposes.

Given its association with the illicit production of MDMA, PMK ethyl glycidate is closely monitored by law enforcement agencies. Forensic laboratories analyze samples containing this compound to track and curb illegal drug manufacturing activities. The ability to detect and identify PMK ethyl glycidate helps authorities enforce drug control laws and prevent the distribution of illegal substances.