Neocuproin hydrochloride monohydrate
[CAS# 303136-82-5]

Identification

• Classification: Chemical reagent >> Organic reagent >> Polycyclic compound
• Name: Neocuproin hydrochloride monohydrate
• Synonyms: 2,9-Dimethyl-1,10-phenanthroline monohydrochloride monohydrate
• Molecular Formula: C₁₄H₁₂N₂^.ClH^.H₂O
• Molecular Weight: 262.73
• CAS Registry Number: 303136-82-5
• EC Number: 628-986-3
• SMILES: CC1=NC2=C(C=C1)C=CC3=C2N=C(C=C3)C.O.Cl

Properties

• Solubility: 25 mg/mL (water)

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H315-H319-H335
• Precautionary Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovory and Applicatios

Neocuproine hydrochloride monohydrate is a derivative of 2,9-dimethyl-1,10-phenanthroline and is an important reagent in analytical chemistry. This compound is known for its high specificity for copper ions and has been widely used in various scientific fields due to its unique chemical properties. Its systematic name is 2,9-dimethyl-1,10-phenanthroline hydrochloride monohydrate.

The discovery of Neocuproine dates back to the early 20th century when chemists were exploring the potential use of phenanthroline derivatives as chelating agents. Neocuproine was identified as a potent ligand for copper ions, forming stable complexes that are well suited for spectrophotometric analysis. Neocuproine hydrochloride monohydrate has a higher solubility in water, which further broadens its application range.

One of the major applications of Neocuproine hydrochloride monohydrate is the determination of copper concentration in various samples. The compound forms a colored complex with copper(I) ions that can be detected and measured using spectrophotometry. This property makes it a valuable tool for analytical chemists who need to quantify trace amounts of copper in environmental samples, biological specimens, and industrial products. The sensitivity and specificity of necuproine for copper ions make it superior to many other reagents used for similar purposes.

In environmental chemistry, necuproine hydrochloride monohydrate is used to monitor copper levels in water and soil. Copper is an essential trace element, but can be toxic in high concentrations. Accurate monitoring is critical for environmental protection and regulatory compliance. Necuproine-based assays can detect even trace amounts of copper, ensuring that any potential contamination is promptly identified and addressed.

In biochemistry, necuproine hydrochloride monohydrate is used to study copper metabolism and its role in various biological processes. Copper is an essential component of a variety of enzymes and is required for the proper functioning of many physiological systems. Using necuproine, researchers can measure copper concentrations in biological tissues and fluids, helping to elucidate the role of this metal in health and disease. This is particularly important in the study of diseases such as Wilson's disease and Menkes disease, which involve abnormal copper metabolism.

Necuproine hydrochloride monohydrate is also used in industrial applications such as quality control of metal products and monitoring of copper in electroplating solutions. The ability to quickly and accurately determine copper levels is essential to maintaining product quality and consistency in manufacturing processes.

In addition to copper detection, neocuproine hydrochloride monohydrate is being explored for its potential in other research areas. For example, its strong chelating properties make it a candidate for studies involving metal ion transport and storage. In addition, its chemical structure inspires the design of new ligands and chelators with tailored properties for specific applications.

Standard laboratory precautions are required for handling and storing neocuproine hydrochloride monohydrate. The compound should be stored in a cool, dry place away from light and moisture to maintain its stability. When preparing solutions, appropriate safety measures should be taken, such as the use of gloves and goggles, to avoid contact with skin and eyes.

References

Alicia Cuevas, Carlos Kremer, Leopoldo Suescun, Alvaro W. Mombr�, Francesc Lloret, Miguel Julve and Juan Faus. Magneto-structural studies on heterobimetallic malonate-bridged MIIReIV complexes (M = Mn, Co, Ni and Cu), Dalton Trans., 2010, 39, 11403.