Methyl 4-chlorobutyrate
[CAS# 3153-37-5]

Identification

• Classification: Chemical reagent >> Organic reagent >> Ester >> Methyl ester compound
• Name: Methyl 4-chlorobutyrate
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.58
• CAS Registry Number: 3153-37-5
• EC Number: 221-592-9
• SMILES: COC(=O)CCCCl

Properties

• Density: 1.12
• Boiling point: 175-176 ºC
• Refractive index: 1.4311-1.4331
• Flash point: 59 ºC

Safety Data

• Hazard Symbols: GHS02;GHS07 Warning
• Hazard Statements: H226-H315-H319-H335
• Precautionary Statements: P210-P233-P240-P241-P242-P243-P261-P264-P264+P265-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Flammable liquids	Flam. Liq.	3	H226
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2A	H319
Eye irritation	Eye Irrit.	2	H319

• Transport Information: UN 3272

Discovory and Applicatios

Methyl 4-chlorobutyrate is an organic compound with the formula C5H9ClO2. It was first synthesized in the mid-20th century as part of research into chlorinated esters and their potential applications. The compound is typically produced by the esterification of 4-chlorobutyric acid with methanol, a process facilitated by acid catalysts.

In organic synthesis, methyl 4-chlorobutyrate is used as a key intermediate. Its structure, featuring both an ester and a chloroalkyl group, makes it highly reactive and suitable for various chemical transformations. It can undergo nucleophilic substitution reactions, where the chlorine atom is replaced by different nucleophiles, allowing the synthesis of a wide range of compounds. The ester group can also be hydrolyzed to produce 4-chlorobutyric acid, which is used in further chemical syntheses.

In the pharmaceutical industry, methyl 4-chlorobutyrate is used to synthesize active pharmaceutical ingredients (APIs) and intermediates. For instance, it can be converted into ?-aminobutyric acid (GABA) analogs, which are important in the treatment of neurological disorders such as epilepsy and anxiety.

Methyl 4-chlorobutyrate is employed in the agrochemical sector to produce herbicides, insecticides, and fungicides. The compound's chlorinated ester structure allows for the development of agrochemicals with specific biological activities, targeting particular pests or pathogens while minimizing harm to the crops.

In materials science, methyl 4-chlorobutyrate is used in the synthesis of polymers and resins. Its reactivity with various monomers can create polymers with unique properties, such as enhanced durability and chemical resistance. These materials are used in coatings, adhesives, and other applications where performance and longevity are critical. The compound's ability to introduce functional groups into polymer chains makes it a useful component in developing advanced materials.

Methyl 4-chlorobutyrate is utilized in academic and industrial research to explore new synthetic methodologies and reaction mechanisms. Researchers use it as a model compound to study substitution reactions, esterification, and other organic processes.

In the flavor and fragrance industry, methyl 4-chlorobutyrate is used as an intermediate to synthesize aroma compounds. Its derivatives can impart fruity and floral notes, enhancing the sensory qualities of various products, including perfumes, food additives, and personal care items.

References

2011. Consecutive Reactions with Sulfoximines: Straightforward Synthesis of Substituted 5,5-Spiroketals. Synthesis, 2011(17).
DOI: 10.1055/s-0030-1260039

1987. Friedel-Crafts alkylation of benzene by normal ω-chloroalkanoic acids and their methyl esters and nitriles. Bulletin of the Academy of Sciences of the USSR, Division of chemical science, 36(2).
DOI: 10.1007/bf00959375

1982. Glass capillary gas chromatography of chlorinated methyl acetates, propanoates and butanoates on Carbowax 20M and SE-30 columns. Chromatographia, 15(8).
DOI: 10.1007/bf02260284