Hexadecyl povidone
[CAS# 32440-50-9]

Identification

• Classification: Organic raw materials >> Ketone compound
• Name: Hexadecyl povidone
• Synonyms: 4 Hexadecyl branches/repeat
• Molecular Formula: C₂₂H₄₁NO
• Molecular Weight: 335.57
• CAS Registry Number: 32440-50-9
• EC Number: 608-741-7
• SMILES: C(CCCCCCCCCC=C)CCCC.C1CCC(N1C=C)=O

Discovory and Applicatios

Hexadecyl povidone is a synthetic amphiphilic polymer derived from polyvinylpyrrolidone (PVP) modified with a hexadecyl (C₁₆) hydrophobic chain. Structurally, it consists of repeating N-vinyl-2-pyrrolidone units forming the hydrophilic backbone, with covalently attached long-chain hexadecyl groups that impart hydrophobic character. This dual nature provides excellent surface activity, making the polymer highly effective as an emulsifier, stabilizer, and dispersant in a variety of formulations.

The development of hexadecyl povidone emerged from efforts to enhance the functional properties of conventional PVP. Polyvinylpyrrolidone itself, first synthesized in the 1930s, gained recognition for its water solubility, film-forming capability, and biocompatibility. Researchers discovered that introducing long hydrophobic chains, such as hexadecyl groups, could create amphiphilic copolymers with tailored solubility and interfacial properties. The hexadecyl modification improved interactions with nonpolar phases while maintaining aqueous solubility to some extent, allowing the polymer to bridge oil–water interfaces effectively.

Applications of hexadecyl povidone span multiple industries. In pharmaceuticals, it functions as a solubilizing agent, stabilizer for emulsions, and excipient in drug delivery systems. Its amphiphilic structure enables it to form micelles or nanoaggregates, which can encapsulate hydrophobic drugs and improve their bioavailability. Additionally, hexadecyl povidone can serve as a film-former in topical formulations, enhancing adhesion and providing controlled release of active ingredients.

In cosmetics and personal care products, the polymer is widely used for hair and skin applications. It provides conditioning effects, improves texture, and enhances moisture retention. Its ability to form thin, flexible films on hair or skin makes it valuable in hair styling products, lotions, and creams. The hydrophobic chains contribute to resistance against humidity, water, and sebum, thereby improving product performance.

Industrial applications include its use as a dispersant, emulsifier, and stabilizer in coatings, inks, and adhesives. The amphiphilic balance allows the polymer to stabilize pigments and maintain uniform dispersions in both aqueous and nonaqueous media. Its long hydrophobic chains improve compatibility with nonpolar components, while the PVP backbone maintains solubility and film-forming properties.

Overall, hexadecyl povidone represents a strategic modification of polyvinylpyrrolidone, combining hydrophilic and hydrophobic segments to achieve amphiphilic behavior. This versatility has made it a critical component in pharmaceutical, cosmetic, and industrial formulations, particularly where stabilization of emulsions, controlled release, or film formation is desired.