Magnesium gluconate
[CAS# 3632-91-5]

Identification

• Classification: Organic raw materials >> Organometallic salt
• Name: Magnesium gluconate
• Synonyms: D-Gluconic acid magnesium salt
• Molecular Formula: C₁₂H₂₂MgO₁₄
• Molecular Weight: 414.60
• CAS Registry Number: 3632-91-5
• EC Number: 222-848-2
• SMILES: C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Mg+2]

Properties

• Flash point: 100.00 ºC (closed cup)

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P280-P305+P351+P338

Discovory and Applicatios

Magnesium gluconate was developed in an effort to create a bioavailable magnesium supplement. It is synthesized by reacting magnesium carbonate or magnesium hydroxide with glucose-derived gluconic acid. This synthesis process was refined in the mid-20th century as researchers sought effective ways to provide the essential mineral. Magnesium gluconate quickly gained acceptance in healthcare and industry for its ability to provide magnesium ions in a soluble and easily absorbed form.

Magnesium gluconate appears as a white or off-white powder or granules, is odorless, and readily soluble in water. It is made up of magnesium ions, Mg+2, chelated with gluconate ions (derived from gluconic acid). This chelation enhances magnesium absorption from the digestive tract, making it an effective agent for replenishing magnesium levels in the body.

Magnesium gluconate is primarily used to treat and prevent magnesium deficiency, which can lead to symptoms such as muscle cramps, fatigue, and irregular heartbeats. Magnesium gluconate is available in a variety of preparations, including tablets, capsules, and liquid solutions. Magnesium gluconate helps support heart health by helping to maintain normal blood pressure and prevent arrhythmias. It is often recommended for people with or at risk for cardiovascular disease. Magnesium gluconate plays a role in neuromuscular function and is sometimes used to manage symptoms of conditions such as migraines and anxiety, where magnesium deficiency may be a contributing factor.

Magnesium gluconate is used to fortify foods and beverages to increase their magnesium content. It is often added to mineral water, nutritional supplements, and fortified foods to enhance their nutritional content without changing the taste or texture. It is the active ingredient in over-the-counter magnesium supplements, providing an easily absorbed source of magnesium for individuals who need dietary supplementation.

In cosmetics, magnesium gluconate is used to moisturize and support skin health. It is used in creams, lotions, and topical treatments designed to improve skin hydration and elasticity. It is also used in hair care products for its conditioning effects, helping to strengthen hair and improve its texture.

Magnesium gluconate is used as an excipient in pharmaceutical formulations to aid in the stability and effectiveness of the drug. It helps maintain the solubility and bioavailability of the active ingredient.

In veterinary medicine, magnesium gluconate is used to address magnesium deficiency in livestock and pets. It helps maintain healthy muscle and nerve function in animals, supporting overall health and productivity.

The high bioavailability of magnesium gluconate means it is effectively absorbed and used by the body, making it an effective supplement for addressing magnesium deficiency. Compared to other magnesium supplements, magnesium gluconate is generally well tolerated and less likely to cause gastrointestinal side effects such as diarrhea or stomach upset. Its solubility and neutral taste make it suitable for a wide range of applications, from dietary supplements to food fortification and cosmetic formulations.

Magnesium gluconate is safe when used as directed. Excessive intake can lead to hypermagnesemia, which is characterized by elevated levels of magnesium in the blood and can cause symptoms such as nausea, muscle weakness, and in severe cases, heart problems. It is critical to follow recommended doses and consult a doctor before taking magnesium supplements, especially for those with kidney disease.

References

2021. Magnesium Supplements in Nutrition. Nutrients, 13(8).
DOI: 10.3390/nu13082789