2-Hydroxypyrimidine hydrochloride
[CAS# 38353-09-2]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Hydroxypyrimidine
• Name: 2-Hydroxypyrimidine hydrochloride
• Synonyms: 2-Pyrimidinol hydrochloride; Pyrimidine-2-ol hydrochloride
• Molecular Formula: C₄H₄N₂O^.HCl
• Molecular Weight: 132.55
• CAS Registry Number: 38353-09-2
• EC Number: 253-897-8
• SMILES: C1=CNC(=O)N=C1.Cl

Properties

• Melting point: 203-205 ºC

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Hazard Statements: H314-H315-H318-H319-H335
• Precautionary Statements: P260-P261-P264-P264+P265-P271-P280-P301+P330+P331-P302+P352-P302+P361+P354-P304+P340-P305+P351+P338-P305+P354+P338-P316-P319-P321-P332+P317-P337+P317-P362+P364-P363-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2A	H319

Discovory and Applicatios

2-Hydroxypyrimidine hydrochloride is a notable chemical compound in the realm of organic chemistry and pharmaceutical research. This compound consists of a pyrimidine ring�a six-membered heterocyclic structure with two nitrogen atoms�and a hydroxyl group (-OH) attached to the 2-position of the pyrimidine ring. When combined with hydrochloric acid, it forms 2-Hydroxypyrimidine hydrochloride, a salt that is commonly used in various chemical processes and applications.

The discovery of 2-Hydroxypyrimidine hydrochloride is rooted in the broader exploration of pyrimidine derivatives, which are integral to many biological and chemical systems. Pyrimidine itself is a fundamental building block in the synthesis of nucleic acids and various bioactive molecules. The introduction of a hydroxyl group at the 2-position provides unique reactivity and functionality, making 2-Hydroxypyrimidine hydrochloride a valuable compound in both synthetic and medicinal chemistry.

One of the primary applications of 2-Hydroxypyrimidine hydrochloride is in pharmaceutical research. The compound serves as a precursor for the synthesis of a variety of bioactive molecules and pharmaceutical agents. Its unique chemical structure enables it to participate in reactions that are useful for developing drugs with targeted biological activities. For instance, the hydroxyl group can be involved in hydrogen bonding interactions, which may influence the binding affinity of drug candidates to their biological targets.

In medicinal chemistry, 2-Hydroxypyrimidine hydrochloride has been investigated for its potential therapeutic properties. Its derivatives have shown promise in various areas, including antiviral and anticancer activities. The ability to modify the pyrimidine ring and introduce additional functional groups allows researchers to explore a wide range of biological activities and optimize compounds for specific therapeutic uses.

The synthesis of 2-Hydroxypyrimidine hydrochloride typically involves the reaction of pyrimidine with hydroxylating agents under controlled conditions. The resulting hydrochloride salt is often used as a stable and soluble form of the compound, which can be easily handled and utilized in further chemical reactions or biological assays.

In addition to its pharmaceutical applications, 2-Hydroxypyrimidine hydrochloride is also employed in organic synthesis as a versatile intermediate. Its reactivity allows it to participate in various chemical transformations, including condensation and substitution reactions. This versatility makes it a valuable building block for the synthesis of complex organic molecules used in research and industrial applications.

Overall, 2-Hydroxypyrimidine hydrochloride is a significant compound with diverse applications in pharmaceutical and organic chemistry. Its unique chemical properties and reactivity make it an important tool for developing new drugs and synthesizing complex molecules, contributing to advancements in both medicinal research and chemical synthesis.