3-Chloro-4-methoxybenzylamine hydrochloride
[CAS# 41965-95-1]

Identification

• Classification: Organic raw materials >> Amino compound >> Acyclic monoamines, polyamines and their derivatives and salts
• Name: 3-Chloro-4-methoxybenzylamine hydrochloride
• Molecular Formula: C₈H₁₀ClNO^.HCl
• Molecular Weight: 208.09
• CAS Registry Number: 41965-95-1
• EC Number: 609-972-6
• SMILES: COC1=C(C=C(C=C1)CN)Cl.Cl

Properties

• Melting point: 250-255 ºC

Safety Data

• Hazard Symbols: GHS05;GHS06 Danger
• Hazard Statements: H301-H318
• Precautionary Statements: P264-P264+P265-P270-P280-P301+P316-P305+P354+P338-P317-P321-P330-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	3	H301
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	1	H301

Discovory and Applicatios

3-Chloro-4-methoxybenzylamine hydrochloride, with the chemical formula C8H10ClNO·HCl, is an organic compound with notable applications in both pharmaceutical and chemical research. This compound features a benzylamine core structure, substituted with a chloro group at the 3-position and a methoxy group at the 4-position on the benzene ring. Its synthesis and applications highlight its importance in advancing scientific and industrial processes.

The discovery and synthesis of 3-chloro-4-methoxybenzylamine hydrochloride emerged from research into benzylamine derivatives. The typical synthesis involves a two-step process starting from 3-chloro-4-methoxybenzaldehyde. This aldehyde is first reacted with an amine to form 3-chloro-4-methoxybenzylamine. The subsequent treatment with hydrochloric acid converts this intermediate into the hydrochloride salt, enhancing its solubility and stability for various applications.

In pharmaceutical research, 3-chloro-4-methoxybenzylamine hydrochloride serves as an important intermediate in the synthesis of a range of therapeutic agents. Its structure, which includes both chloro and methoxy groups, allows for the introduction of additional functional groups. This capability is valuable in drug development, particularly in creating compounds that target the central nervous system. Derivatives of this substance are explored for their potential as antidepressants, anxiolytics, and other therapeutic agents. The compound’s versatility in modifying biological activity through structural alterations makes it a crucial tool in designing new pharmaceuticals with specific effects.

The compound also finds significant use in chemical synthesis. Its unique structure enables participation in various chemical transformations, making it a valuable reagent for preparing complex organic molecules. The presence of the chloro and methoxy substituents provides sites for further modification, facilitating the synthesis of dyes, specialty chemicals, and other organic compounds. This versatility in synthetic applications underscores the compound's utility in advancing organic chemistry and materials science.

Research and development activities continue to explore new applications of 3-chloro-4-methoxybenzylamine hydrochloride. Scientists are investigating its potential in synthesizing advanced materials and novel therapeutic agents. The compound’s reactivity and ability to undergo diverse chemical transformations make it an attractive candidate for further exploration in both industrial and research settings.

Overall, 3-chloro-4-methoxybenzylamine hydrochloride plays a significant role in pharmaceutical and chemical research. Its use as an intermediate and reagent highlights its value in developing new drugs and synthesizing complex organic molecules. The ongoing research into its applications demonstrates its importance in advancing scientific and industrial processes.