3-Mercaptopropyl Silica Gel (0.5-0.8mmol/g)
[CAS# 438582-69-5]

Identification

• Classification: Organic raw materials >> Organosilicon compound
• Name: 3-Mercaptopropyl Silica Gel (0.5-0.8mmol/g)
• Molecular Formula: (-Si(CH₂)_3SH)_n
• CAS Registry Number: 438582-69-5
• SMILES: SCC[Si]

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Discovory and Applicatios

3-Mercaptopropyl silica gel, with a functionalization density of 0.5-0.8 mmol/g, represents a specialized form of silica gel modified with mercaptopropyl groups. This modification enhances its utility in various chemical applications, primarily in the fields of chromatography, catalysis, and material science.

The development of 3-mercaptopropyl silica gel originated from efforts to improve the functionality and selectivity of silica-based materials. Silica gel, a widely used adsorbent in chromatography and as a support for catalysts, has its properties significantly altered by chemical modification. The introduction of mercaptopropyl groups onto the silica surface is achieved through a silylation reaction, where a mercaptopropylsilane reagent reacts with hydroxyl groups on the silica surface. This process results in the covalent attachment of mercaptopropyl groups, imparting specific chemical functionalities to the silica gel.

The resulting 3-mercaptopropyl silica gel is characterized by the presence of thiol (-SH) groups attached to the silica surface. This functionalization endows the silica gel with unique properties, including enhanced reactivity towards a variety of chemical species. The thiol groups on the surface can participate in various chemical reactions, making the modified silica gel a versatile tool in organic synthesis and material preparation.

One of the primary applications of 3-mercaptopropyl silica gel is in chromatography, particularly in separation and purification processes. The thiol groups can interact with specific analytes through affinity interactions, providing a method for selective separation. This functionality is especially useful in the separation of compounds with thiol-reactive groups or in the removal of heavy metals from solutions. Additionally, 3-mercaptopropyl silica gel is employed in the preparation of chiral stationary phases for enantioselective chromatography, where the thiol groups can form coordination complexes with chiral molecules, aiding in the separation of enantiomers.

In catalysis, 3-mercaptopropyl silica gel serves as a support for various catalytic reactions. The thiol groups can act as ligands or reactive sites for metal catalysts, facilitating heterogeneous catalytic processes. For instance, metal ions such as palladium or platinum can be anchored to the thiol groups, creating effective catalysts for reactions like hydrogenation or cross-coupling. This application is particularly valuable in green chemistry, where recyclable and reusable catalysts are sought to reduce waste and environmental impact.

The material is also used in materials science and nanotechnology. In these fields, 3-mercaptopropyl silica gel can be functionalized further to create hybrid materials with tailored properties. The thiol groups can form covalent bonds with various organic or inorganic compounds, enabling the development of advanced materials with specific chemical and physical characteristics. For example, 3-mercaptopropyl silica gel has been utilized in the synthesis of nanocomposites and sensor materials, where the thiol groups contribute to the material's responsiveness to external stimuli or target analytes.

In summary, 3-mercaptopropyl silica gel with a functionalization density of 0.5-0.8 mmol/g represents a significant advancement in the field of functionalized silica materials. Its versatile applications in chromatography, catalysis, and materials science highlight its importance as a tool for selective separation, catalytic reactions, and the development of advanced materials.