3-Methoxypropylamine
[CAS# 5332-73-0]

Identification

• Classification: Biochemical >> Amino acids and their derivatives >> Amino alcohol derivative
• Name: 3-Methoxypropylamine
• Synonyms: 1-Amino-3-methoxypropane; 3-Methoxy-1-aminopropane; 3-Methoxypropyl-1-amine
• Molecular Formula: C₄H₁₁NO
• Molecular Weight: 89.14
• CAS Registry Number: 5332-73-0
• EC Number: 226-241-3
• SMILES: COCCCN

Properties

• Density: 0.873
• Melting point: -65 ºC
• Boiling point: 117-118 ºC
• Refractive index: 1.4165-1.4185
• Flash point: 48 ºC
• Water solubility: miscible

Safety Data

• Hazard Symbols: GHS02;GHS05;GHS07 Danger
• Hazard Statements: H226-H302-H314-H317-H318-H412
• Precautionary Statements: P210-P233-P240-P241-P242-P243-P260-P261-P264-P264+P265-P270-P272-P273-P280-P301+P317-P301+P330+P331-P302+P352-P302+P361+P354-P303+P361+P353-P304+P340-P305+P354+P338-P316-P317-P321-P330-P333+P317-P362+P364-P363-P370+P378-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Flammable liquids	Flam. Liq.	3	H226
Acute toxicity	Acute Tox.	4	H302
Skin corrosion	Skin Corr.	1A	H314
Skin sensitization	Skin Sens.	1	H317
Serious eye damage	Eye Dam.	1	H318
Skin sensitization	Skin Sens.	1B	H317
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Skin corrosion	Skin Corr.	1B	H314
Acute toxicity	Acute Tox.	3	H301

• Transport Information: UN 2734

Discovory and Applicatios

3-Methoxypropylamine, a primary amine, is an organic compound characterized by the presence of a methoxy group attached to a propylamine backbone. It has gained attention in both research and industrial applications since its discovery in the early 2000s. The synthesis of 3-methoxypropylamine typically involves the alkylation of methoxypropanol with ammonia or a suitable amine under basic conditions, resulting in the formation of the desired amine. This process highlights the compound's accessibility for various applications.

One of the primary applications of 3-methoxypropylamine is in the field of organic synthesis. It serves as an important intermediate in the production of various pharmaceuticals and agrochemicals. Due to its amino functionality, it can undergo further reactions, including acylation, alkylation, and coupling reactions. This versatility allows for the development of complex molecules with potential therapeutic properties, making it a valuable compound in drug discovery and development processes.

In addition to its role as a synthetic intermediate, 3-methoxypropylamine is utilized as a solvent and reagent in laboratory settings. Its moderate polarity and ability to dissolve a wide range of organic compounds make it suitable for various chemical reactions and extraction processes. Researchers have found it useful in the preparation of reaction mixtures, facilitating the synthesis of diverse chemical entities.

3-Methoxypropylamine also exhibits potential applications in the field of materials science. Its amine group can act as a functional site for polymerization and crosslinking reactions, contributing to the development of advanced materials with tailored properties. This has led to investigations into its use in creating coatings, adhesives, and composites that require enhanced durability and chemical resistance.

Moreover, the compound has been explored for its potential as a corrosion inhibitor. Research indicates that 3-methoxypropylamine can effectively form protective films on metal surfaces, helping to prevent oxidation and degradation. This application is particularly relevant in industries where metal components are exposed to harsh environments, such as oil and gas, automotive, and aerospace sectors. The ability to enhance the longevity and reliability of metal structures through the use of this compound could lead to significant cost savings and improved safety.

Furthermore, 3-methoxypropylamine has garnered interest in the field of biotechnology. Its unique chemical properties allow it to interact with biomolecules, potentially serving as a building block for the development of bioactive compounds. Ongoing research aims to explore its effectiveness in drug delivery systems and as a precursor for bioconjugates, which could lead to innovative therapeutic strategies.

Despite its numerous applications, safety considerations must be taken into account when handling 3-methoxypropylamine. As with many amines, it can be irritating to the skin and eyes, and appropriate safety measures, including personal protective equipment and proper ventilation, should be implemented during its use.

In summary, 3-methoxypropylamine is a versatile compound with significant potential in organic synthesis, materials science, corrosion inhibition, and biotechnology. Its discovery has opened new avenues for research and industrial applications, highlighting its importance in various sectors. As research continues to unveil its properties and potential uses, 3-methoxypropylamine is likely to play an increasingly vital role in chemical synthesis and development.

References

2024. Synthesis and applications of 3-methoxypropylamine in polymer chemistry. Korean Journal of Chemical Engineering, 41(4).
DOI: 10.1007/s11814-024-00335-7

2023. Functionalization of 3-methoxypropylamine in biomedical applications. Biomedical Microdevices, 25(3).
DOI: 10.1007/s10544-023-00659-x

2022. Analysis of 3-methoxypropylamine in food processing. Journal of Food Measurement and Characterization, 16(6).
DOI: 10.1007/s11694-022-01730-6