Glycerol tris[poly(propylene glycol)amine terminated] ether
[CAS# 64852-22-8]

Identification

• Classification: Catalysts and additives >> Polymer
• Name: Glycerol tris[poly(propylene glycol)amine terminated] ether
• Molecular Formula: (C₃H₆O)_n(_C3H6O)_n(_C3H6O)_nC12H29N3O3
• CAS Registry Number: 64852-22-8
• EC Number: 682-477-0

Properties

• Density: 1 g/mL (25 ºC)
• Flash point: 113 ºC
• Flash point: 113 ºC

Safety Data

• Hazard Symbols: Xi
• Risk Codes: R36/37/38;R41
• Safety Description: S26;S36

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318
Skin irritation	Skin Irrit.	2	H315
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Acute toxicity	Acute Tox.	4	H302
Acute toxicity	Acute Tox.	4	H312
Skin corrosion	Skin Corr.	1B	H314
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Acute toxicity	Acute Tox.	3	H301
Skin corrosion	Skin Corr.	1C	H314
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2	H319

Discovory and Applicatios

Glycerol tris[poly(propylene glycol)amine terminated] ether is a specialized chemical compound that has garnered attention for its unique properties and versatile applications. This compound belongs to the class of polyetheramines, which are synthesized through the reaction of glycerol with poly(propylene glycol) (PPG) and amines. The synthesis involves a multi-step process where glycerol serves as the backbone, and the incorporation of PPG creates a flexible and hydrophilic polymer structure. The discovery of this compound can be traced back to ongoing research in polymer chemistry aimed at developing materials with enhanced performance characteristics, particularly in the field of surfactants and additives.

One of the primary applications of glycerol tris[poly(propylene glycol)amine terminated] ether is as a surfactant in various industrial formulations. Its amphiphilic nature allows it to effectively reduce surface tension, making it an excellent candidate for use in emulsions, foams, and dispersions. This property is particularly valuable in the formulation of personal care products, including lotions, creams, and hair care products, where it helps to stabilize mixtures of oil and water.

In addition to its role as a surfactant, this compound also exhibits excellent compatibility with a wide range of other materials, including solvents, polymers, and active ingredients. This compatibility enhances its utility in formulating various products across different industries. In the paint and coatings sector, for instance, glycerol tris[poly(propylene glycol)amine terminated] ether is used to improve the stability and performance of coatings by enhancing their wetting and dispersion properties.

Moreover, the compound is also recognized for its application in the pharmaceutical industry, particularly in drug delivery systems. Its ability to form stable complexes with active pharmaceutical ingredients (APIs) allows for improved solubility and bioavailability. This characteristic makes it an attractive candidate for developing formulations of poorly soluble drugs, thereby enhancing their therapeutic effectiveness.

In the field of agriculture, glycerol tris[poly(propylene glycol)amine terminated] ether is utilized in the formulation of agrochemicals. Its surfactant properties aid in the efficient application of pesticides and herbicides, ensuring better coverage and adhesion to plant surfaces. This enhances the efficacy of the active ingredients and reduces waste through more effective application.

The compound also finds applications in the manufacturing of flexible polyurethane foams, adhesives, and sealants. Its unique structure provides the necessary flexibility and durability required in these applications, contributing to the production of high-performance materials that meet stringent industry standards.

Despite its many advantages, there are ongoing studies to evaluate the environmental impact and safety profile of glycerol tris[poly(propylene glycol)amine terminated] ether. As with any chemical substance, it is crucial to assess its biodegradability and potential effects on human health and the environment to ensure sustainable use.

In summary, glycerol tris[poly(propylene glycol)amine terminated] ether is a multifunctional compound with significant applications in various sectors, including personal care, pharmaceuticals, agriculture, and industrial formulations. Its discovery and development represent a vital step in the advancement of chemical substances that meet the evolving needs of modern industries.

References

Higgins, J. L., & Wright, A. M. (2010). Polyetheramines: A Review of Their Properties and Applications. Journal of Applied Polymer Science, 118(5), 2856-2865.

Zhang, J., et al. (2013). Applications of Polyetheramines in the Synthesis of High-Performance Materials. Materials Science and Engineering: C, 33(4), 2000-2007.

Bhardwaj, A., et al. (2017). Surfactants in Pharmaceutical Formulations: A Review. International Journal of Pharmaceutical Sciences and Research, 8(12), 4813-4820.