Chitosan hydrochloride
[CAS# 70694-72-3]

Identification

• Classification: Analytical chemistry >> Standard >> Pharmacopoeia standards and magazine standards
• Name: Chitosan hydrochloride
• Synonyms: Poliglusam hydrochloride
• CAS Registry Number: 70694-72-3
• EC Number: 615-145-0

Discovory and Applicatios

Chitosan hydrochloride is a water-soluble derivative of chitosan, a biopolymer obtained by the deacetylation of chitin. Chitin itself is found in the exoskeletons of crustaceans, insects, and fungi. Chitosan hydrochloride is produced by reacting chitosan with hydrochloric acid, resulting in a product that is more easily soluble in water than the parent chitosan. This enhanced solubility opens up a broader range of applications, particularly in the pharmaceutical, biomedical, and cosmetic industries.

The discovery and use of chitosan hydrochloride were driven by the need for a more soluble form of chitosan that could be effectively used in various biological systems. While chitosan is recognized for its biocompatibility, biodegradability, and non-toxicity, its limited solubility in water posed challenges for practical applications. The formation of chitosan hydrochloride improved its solubility across a wide pH range, making it more versatile for industrial and medical uses.

One of the primary applications of chitosan hydrochloride is in drug delivery systems. Due to its ability to form hydrogels and nanoparticles, it is used as a carrier for both hydrophilic and hydrophobic drugs, enhancing their bioavailability and providing controlled release mechanisms. This has proven particularly beneficial in the formulation of oral, topical, and injectable drugs. Additionally, chitosan hydrochloride exhibits mucoadhesive properties, which make it useful for nasal or buccal drug delivery systems, where prolonged retention and absorption are critical for therapeutic efficacy.

In the biomedical field, chitosan hydrochloride is used in wound dressings and tissue engineering. Its biocompatibility and hemostatic properties make it effective in accelerating wound healing and reducing bleeding. The material also supports cell growth and tissue regeneration, which is essential in scaffolds for tissue engineering. Chitosan hydrochloride’s antimicrobial properties further enhance its utility in wound care, providing protection against infections during the healing process.

In the cosmetic industry, chitosan hydrochloride is used in skincare and haircare formulations. Its ability to form protective films on the skin and hair, along with its moisturizing properties, makes it a valuable ingredient in products designed to improve hydration and elasticity. Its biocompatibility ensures that it is well-tolerated by most skin types, making it suitable for use in formulations for sensitive skin.

The versatility and bioactive properties of chitosan hydrochloride have made it an essential component in various fields, particularly where biocompatibility and solubility are critical factors in product performance.