Chitin
[CAS# 1398-61-4]

Identification

• Classification: Biochemical >> Carbohydrate >> Polysaccharide
• Name: Chitin
• Synonyms: beta-(1,4)-2-Acetamido-2-deoxy-D-glucose
• Molecular Formula: (C₈H₁₃NO₅)_n
• CAS Registry Number: 1398-61-4
• EC Number: 215-744-3
• SMILES: CC(=O)N[C@@H]1[C@H](O)O[C@@H](CO)[C@H](O)[C@H]1O

Properties

• Water solubility: insoluble
• Density: 1.6±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.620, Calc.^*
• Boiling Point: 1139.9±65.0 ºC (760 mmHg), Calc.^*
• Flash Point: 643.2±34.3 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Safety Description: S24/25

Discovory and Applicatios

Chitin is a natural polymer that is found in the exoskeletons of arthropods, the cell walls of fungi, and the shells of crustaceans such as shrimp and crabs. It is composed of N-acetylglucosamine, a derivative of glucose, and is the second most abundant polysaccharide in nature after cellulose. The discovery of chitin dates back to the early 19th century when the French chemist Henri Braconnot first identified it in the cuticle of insects and the shells of crustaceans. Over the years, its importance in various biological processes and its potential for commercial applications have been increasingly recognized.

The structure of chitin consists of long chains of N-acetylglucosamine units, which are linked together by beta-1,4-glycosidic bonds. This structure gives chitin its high strength and rigidity, making it an important component of the exoskeletons of insects, crustaceans, and the cell walls of fungi. Due to its biocompatibility and biodegradability, chitin has attracted significant attention for various applications, particularly in the fields of medicine, agriculture, and materials science.

One of the most notable applications of chitin is in the production of chitosan, a deacetylated derivative of chitin. Chitosan has been widely used in medical and pharmaceutical applications due to its biocompatibility, antimicrobial properties, and ability to form films and gels. It is used in wound dressings, drug delivery systems, and as a fat-binding agent in weight loss supplements. Chitosan is also explored for its potential in tissue engineering, as it can support the growth of cells and tissues, making it useful for creating scaffolds in regenerative medicine.

In addition to its medical uses, chitin and its derivatives have several applications in agriculture. Chitosan, for example, is used as a natural pesticide and fungicide due to its ability to induce resistance in plants against pathogens. It is also used as a soil conditioner and growth promoter, helping to improve crop yields and soil health. Furthermore, chitin is being researched as a potential sustainable alternative to synthetic polymers in the production of biodegradable plastics. Its use in bioplastics is part of the broader effort to reduce reliance on petroleum-based plastics and mitigate environmental pollution.

Chitin has also found applications in water treatment, where it is used to remove heavy metals and other contaminants from water. Its ability to form complexes with metal ions allows it to function as an effective adsorbent in water purification systems. Additionally, chitin has been investigated for use in food preservation, as its antimicrobial properties can help extend the shelf life of perishable goods by inhibiting the growth of bacteria and fungi.

Despite its many potential uses, the commercial production of chitin and chitosan remains relatively expensive due to the complex and energy-intensive processes involved in extracting and processing chitin from natural sources. Research into more efficient extraction methods and the development of new applications continues to drive interest in chitin as a sustainable and versatile material.

References

2025. Highly-efficient co-production of microbial lipid and magnesium ammonium phosphate from N-acetyl-D-glucosamine. Bioresource Technology, 416, 131781.
DOI: 10.1016/j.biortech.2024.131781

2024. Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase. Molecular Metabolism, 90, 102060.
DOI: 10.1016/j.molmet.2024.102060

2024. Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation. Trends in Cell Biology, 34(12), 1041-1054.
DOI: 10.1016/j.tcb.2024.10.007