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6-Methoxynicotinamide
[CAS# 7150-23-4]

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Identification
Classification Organic raw materials >> Amino compound >> Amide compound
Name 6-Methoxynicotinamide
Synonyms JBSNF-000088
Molecular Structure CAS # 7150-23-4, 6-Methoxynicotinamide, JBSNF-000088
Molecular Formula C7H8N2O2
Molecular Weight 152.15
CAS Registry Number 7150-23-4
EC Number 802-004-5
SMILES COC1=NC=C(C=C1)C(=O)N
Properties
Density 1.2±0.1 g/cm3, Calc.*
Index of Refraction 1.550, Calc.*
Boiling Point 301.6±22.0 ºC (760 mmHg), Calc.*
Flash Point 136.2±22.3 ºC, Calc.*
* Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbols symbol   GHS07 Warning    Details
Hazard Statements H315-H319-H335    Details
Precautionary Statements P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501    Details
SDS Available
up Discovory and Applicatios
6-Methoxynicotinamide is an organic compound derived from nicotinamide, a form of niacin or vitamin B3, which is essential for various metabolic processes in the human body. This compound is characterized by a methoxy group (-OCH3) attached to the 6-position of the pyridine ring, a modification that can significantly influence its chemical and biological properties. The discovery and application of 6-methoxynicotinamide have been driven by its structural similarity to nicotinamide and the potential for its use in a range of fields, including biochemistry, pharmaceuticals, and agriculture.

The discovery of 6-methoxynicotinamide is rooted in the broader study of nicotinamide derivatives, which have garnered attention due to their diverse biological activities. Nicotinamide itself is involved in the synthesis of nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular metabolism, and modifications to its structure can lead to compounds with altered biological activities. The methoxy modification at the 6-position of nicotinamide is believed to enhance the compound’s ability to interact with certain enzymes and receptors, offering new avenues for therapeutic applications.

One of the key applications of 6-methoxynicotinamide lies in its potential as a therapeutic agent. The compound has been investigated for its ability to modulate various biological processes, including its role in inhibiting certain enzymes and acting as an anti-inflammatory agent. For example, studies have suggested that 6-methoxynicotinamide can influence the activity of sirtuins, a family of enzymes involved in regulating cellular health, aging, and metabolism. This has sparked interest in its use for age-related diseases, as well as conditions associated with oxidative stress and inflammation. The compound's ability to modulate the sirtuin pathway makes it a candidate for research into metabolic disorders and neurodegenerative diseases, such as Alzheimer's disease.

Furthermore, 6-methoxynicotinamide has shown potential in the field of cancer research. Some studies suggest that nicotinamide derivatives, including 6-methoxynicotinamide, may exhibit antitumor effects by influencing cellular signaling pathways and promoting apoptosis (programmed cell death) in cancer cells. While more research is needed to fully understand its mechanism of action, the compound's ability to interact with molecular targets within tumor cells positions it as a promising lead compound for anticancer drug development.

In addition to its potential therapeutic uses, 6-methoxynicotinamide has applications in agriculture, where it has been explored for its pesticidal properties. Like other nicotinamide derivatives, it may possess antifungal or antibacterial activities, making it useful in protecting crops from various pathogens. The compound's ability to inhibit the growth of fungi and bacteria could contribute to its use in agricultural formulations aimed at improving crop yields and minimizing the impact of plant diseases.

The compound's synthesis is relatively straightforward, involving the methoxylation of nicotinamide using common reagents such as methylating agents. This simple synthetic route makes 6-methoxynicotinamide accessible for use in research and development, particularly in the fields of drug discovery and agricultural chemistry. However, the compound's stability, solubility, and bioavailability in biological systems are areas of ongoing study, as these factors will influence its effectiveness and safety in clinical and agricultural applications.

As research progresses, the full potential of 6-methoxynicotinamide continues to unfold. While its therapeutic applications in neurodegenerative diseases, cancer, and metabolic disorders are promising, much remains to be explored in terms of its mechanism of action and clinical efficacy. Similarly, its agricultural potential could offer new solutions for crop protection, but further investigation is required to establish its commercial viability.
Market Analysis Reports
List of Reports Available for 6-Methoxynicotinamide
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