Trimethoprim
[CAS# 738-70-5]

Identification

• Classification: API >> Synthetic anti-infective drugs >> Sulfonamides and synergists
• Name: Trimethoprim
• Synonyms: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; 5-(3,4,5-Trimethoxybenzyl)-2,4-diaminopyrimidine; 5-((3,4,5-Trimethoxyphenyl)methyl)-2,4-pyrimidinediamine; Abaprim
• Molecular Formula: C₁₄H₁₈N₄O₃
• Molecular Weight: 290.32
• CAS Registry Number: 738-70-5
• EC Number: 212-006-2

Properties

• Melting point: 199-203 ºC
• Water solubility: <0.1 g/100 mL at 24 ºC

Safety Data

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Reproductive toxicity	Repr.	2	H361
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Specific target organ toxicity - repeated exposure	STOT RE	1	H372
Acute toxicity	Acute Tox.	4	H332
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Germ cell mutagenicity	Muta.	2	H341
Acute toxicity	Acute Tox.	4	H312
Reproductive toxicity	Repr.	1B	H360
Respiratory sensitization	Resp. Sens.	1	H334
Skin sensitization	Skin Sens.	1	H317
Acute toxicity	Acute Tox.	3	H301
Reproductive toxicity	Repr.	2	H361d
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Reproductive toxicity	Repr.	1A	H360
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Eye irritation	Eye Irrit.	2A	H319