Mercury chloride
[CAS# 7487-94-7]

Identification

• Classification: API >> Synthetic anti-infective drugs >> Disinfectant antiseptic
• Name: Mercury chloride
• Synonyms: Mercury dichloride
• Molecular Formula: HgCl₂
• Molecular Weight: 271.50
• CAS Registry Number: 7487-94-7
• EC Number: 231-299-8
• SMILES: Cl[Hg]Cl

Properties

• Density: 5.43 g/mL (Expl.)
• Melting point: 277 ºC (Expl.)
• Boiling point: 302 ºC (Expl.)
• Solubility: 7.4 g/100 mL (20 ºC) (Expl.)
• Refraction index: 1.859 (Expl.)

Safety Data

• Hazard Symbols: GHS05;GHS06;GHS08;GHS09 Danger
• Hazard Statements: H300-H314-H341-H361f-H372-H400-H410
• Precautionary Statements: P203-P260-P264-P270-P273-P280-P301+P316-P301+P330+P331-P302+P361+P354-P304+P340-P305+P354+P338-P316-P318-P319-P321-P330-P363-P391-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin corrosion	Skin Corr.	1B	H314
Specific target organ toxicity - repeated exposure	STOT RE	1	H372
Acute toxicity	Acute Tox.	2	H300
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Germ cell mutagenicity	Muta.	2	H341
Reproductive toxicity	Repr.	2	H361
Skin sensitization	Skin Sens.	1	H317
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	1	H310
Acute toxicity	Acute Tox.	2	H330
Reproductive toxicity	Repr.	2	H361f

• Transport Information: UN 1624

Discovory and Applicatios

Mercury chloride, also known as mercuric chloride or HgCl₂, is a white crystalline solid that has been historically significant in both scientific research and practical applications. This compound consists of one mercury atom in the +2 oxidation state and two chloride ions. It is highly toxic, soluble in water, and has been extensively used in a wide range of fields including medicine, analytical chemistry, agriculture, and industry.

Mercuric chloride was known and used as early as the Middle Ages. Alchemists and early physicians referred to it as "sublimate of mercury" due to its ability to sublime when heated. Its antiseptic properties were noted by early practitioners, leading to its widespread use as a topical disinfectant and preservative in the 18th and 19th centuries. In the medical field, it was applied as an antiseptic and treatment for syphilis prior to the discovery of safer antibiotics such as penicillin. However, due to its high toxicity and potential for mercury poisoning, its medical use declined dramatically in the 20th century.

In analytical chemistry, HgCl₂ has been used in precipitation reactions and qualitative analysis. It forms stable complexes with ammonia and other ligands, which made it a valuable reagent for studying coordination chemistry and reaction mechanisms. It was also employed as a standard oxidizing agent in redox titrations and as a catalyst in organic syntheses.

In agriculture, mercuric chloride was formerly used as a fungicide and pesticide, particularly for treating seeds and bulbs to prevent fungal infections and pest damage. However, due to growing awareness of mercury’s environmental persistence and bioaccumulative properties, such uses have been banned or heavily restricted in many countries since the late 20th century. Regulatory changes were prompted by studies that demonstrated the long-term ecological damage caused by mercury compounds, especially their impact on aquatic life.

Industrially, HgCl₂ has been used in the production of other mercury compounds, in electroplating, and in photographic processing. It was also utilized in wood preservation and as a component of batteries and electrolytes. However, the same environmental and health concerns that led to its ban in medical and agricultural applications have also resulted in declining industrial use. Safer and less toxic alternatives have replaced mercury chloride in many processes, and its handling is now strictly controlled under international agreements such as the Minamata Convention on Mercury.

The toxicity of mercury chloride is attributed to its ability to bind with thiol groups in proteins, thereby interfering with enzyme function and cellular processes. Exposure can occur via ingestion, inhalation, or skin contact and can lead to symptoms such as abdominal pain, kidney damage, neurological disturbances, and, in severe cases, death. This risk necessitates stringent safety measures in laboratories and industries where the compound is still used.

Despite its diminished practical use today, mercury chloride remains an important compound in the historical development of chemistry and toxicology. It is still studied for its chemical properties and role in mercury cycling in the environment. Researchers continue to investigate its interactions with organic molecules and its behavior in various environmental matrices, contributing to a better understanding of mercury pollution and its mitigation.

References

1991. Inhibition of metabolic coupling by metals. Journal of Toxicology and Environmental Health, 32(1).
DOI: 10.1080/15287399109531463

1986. Autoimmunity induced by HgCl2 in Brown-Norway rats. I. Production of monoclonal antibodies. Journal of immunology (Baltimore, Md. : 1950), 136(9).
DOI: 10.4049/jimmunol.136.9.3272

1990. Proton NMR monitoring of the onset and recovery of experimental renal damage. Journal of Pharmaceutical and Biomedical Analysis, 8(1).
DOI: 10.1016/0731-7085(90)80150-n