Chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']manganese
[CAS# 81065-76-1]

Identification

• Classification: Biochemical >> Inhibitor >> Neuronal signaling >> Beta amyloid inhibitor
• Name: Chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']manganese
• Molecular Formula: C₁₈H₁₈ClMnN₂O₄
• Molecular Weight: 416.74
• CAS Registry Number: 81065-76-1
• SMILES: COC1=CC=CC(=C1[O-])C=NCCN=CC2=C(C(=CC=C2)OC)[O-].[Cl-].[Mn+3]

Properties

• Solubility: 0.0121 mg/mL (water)

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302
• Precautionary Statements: P280-P305+P351+P338

Discovory and Applicatios

Chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylene)]bis[6-methoxyphenol]](2-)-N2,N2',O1,O1' ] Manganese, commonly known as Mn-Salen, belongs to the salen ligand family and is a multifunctional coordination compound. Mn-Salen is synthesized by reacting manganese(II) chloride with the corresponding Salen ligand, thereby forming a stable coordination complex with the chlorine ligand bound to the manganese center.

Mn-Salen complexes are widely used as catalysts in organic synthesis reactions, including oxidation, reduction and asymmetric transformations. The unique coordination environment of the manganese center and the tunable properties of the salen ligand enable the Mn-Salen complex to exhibit high catalytic activity and selectivity in various chemical transformations. Mn-Salen complexes are particularly effective catalysts for oxidation reactions, including epoxidation, hydroxylation and oxidative cleavage of double bonds. These reactions play an important role in the synthesis of pharmaceutical intermediates, natural products, and specialty chemicals. Mn-Salen catalysts promote the selective insertion of oxygen atoms into organic substrates, leading to the formation of valuable oxidation products with high yields and stereochemical control. Mn-Salen complexes have been widely used in asymmetric synthesis. They can serve as chiral catalysts to enantioselectively convert prochiral substrates into optically active products. The chiral environment created by the salen ligand imparts stereochemical control to the catalytic process, enabling the synthesis of enantiomerically enriched compounds with high levels of stereoselectivity. Mn-Salen complexes comply with environmentally friendly reaction conditions and green chemistry principles, making them attractive catalysts in sustainable chemical processes. Many Mn-Salen catalyzed reactions are performed under mild reaction conditions, using benign solvents, and generate minimal waste, helping to reduce environmental impact and improve the sustainability of chemical synthesis. Mn-Salen complexes have shown potential for biological applications, including metalloenzyme mimetics, MRI contrast agents, and therapeutic agents for the treatment of disease. The unique coordination chemistry of Mn-Salen complexes enables them to interact with biological systems and regulate cellular processes, making them promising candidates for biomedical research and drug development.