tert-Butyldicyclohexylphosphine
[CAS# 93634-87-8]

Identification

• Classification: Organic raw materials >> Organic phosphine compound
• Name: tert-Butyldicyclohexylphosphine
• Synonyms: Dicyclohexyltert-butylphosphine
• Molecular Formula: C₁₆H₃₁P
• Molecular Weight: 254.39
• CAS Registry Number: 93634-87-8
• EC Number: 627-520-6
• SMILES: CC(C)(C)P(C1CCCCC1)C2CCCCC2

Properties

• Solubility: Insoluble (3.1E^-4 g/L) (25 ºC), Calc.^*
• Boiling Point: 333.4±9.0 ºC (760 mmHg), Calc.^*
• Flash Point: 162.8±25.0 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2013 ACD/Labs)

Safety Data

• Hazard Symbols: GHS02 Danger
• Hazard Statements: H250
• Precautionary Statements: P210-P222-P231-P233-P280-P302+P335+P334-P370+P378

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Pyrophoric liquids	Pyr. Liq.	1	H250
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315

• Transport Information: UN 2845 4.2/PG 1

Discovory and Applicatios

tert-Butyldicyclohexylphosphine is a specialized organophosphorus compound with significant applications in the field of organometallic chemistry and catalysis. Its structure, characterized by the presence of a tert-butyl group and two cyclohexyl groups attached to a phosphine moiety, imparts distinctive chemical properties that make it valuable in various industrial and research contexts.

The discovery of tert-Butyldicyclohexylphosphine can be traced back to the ongoing quest for novel phosphine ligands that offer enhanced stability and reactivity in coordination chemistry. The synthesis of this compound typically involves the reaction of dicyclohexylphosphine with tert-butyl chloride in the presence of a suitable base. This process allows for the introduction of the tert-butyl group, which plays a crucial role in modulating the electronic and steric properties of the phosphine ligand.

One of the primary applications of tert-Butyldicyclohexylphosphine is in the field of homogeneous catalysis. The compound serves as a versatile ligand in various catalytic processes, including cross-coupling reactions and hydrogenation. Its sterically hindered structure provides excellent stability to the metal-phosphine complexes, enhancing their catalytic activity and selectivity. This property makes tert-Butyldicyclohexylphosphine particularly useful in industrial processes where high performance and durability are required.

In cross-coupling reactions, such as the Suzuki and Heck reactions, tert-Butyldicyclohexylphosphine is employed to facilitate the coupling of different organic substrates. The phosphine ligand coordinates to transition metal catalysts, improving their efficiency and selectivity in forming C-C bonds. This application is of significant importance in the synthesis of complex organic molecules and pharmaceutical intermediates.

The compound is also utilized in hydrogenation reactions, where it acts as a ligand in metal-catalyzed hydrogenation of alkenes and alkynes. The stability imparted by the tert-butyl and cyclohexyl groups enhances the performance of the catalyst, making it suitable for use in various chemical transformations. This application is crucial in the production of fine chemicals and pharmaceuticals, where precise control over hydrogenation processes is essential.

Additionally, tert-Butyldicyclohexylphosphine has been explored in the development of new materials and chemical sensors. Its unique structure and reactivity enable the formation of novel metal-phosphine complexes with potential applications in material science. For example, the compound can be used to create materials with tailored electronic and optical properties, which are useful in electronic devices and sensors.

The compound's role in research and development extends to its use in organometallic chemistry for the synthesis of novel catalysts and materials. Its ability to form stable complexes with various transition metals makes it a valuable tool for investigating new chemical reactions and processes. Researchers continue to explore the potential of tert-Butyldicyclohexylphosphine in developing advanced materials and improving existing catalytic systems.

In summary, tert-Butyldicyclohexylphosphine is a significant organophosphorus compound with diverse applications in catalysis, materials science, and chemical research. Its stability and reactivity, conferred by its unique structure, make it a valuable ligand in various chemical processes. The ongoing exploration of its properties and applications continues to contribute to advancements in chemistry and industry.