Ademetionine disulfate tosylate
[CAS# 97540-22-2]

Identification

• Classification: Biochemical >> Amino acids and their derivatives >> Methionine derivatives
• Name: Ademetionine disulfate tosylate
• Synonyms: S-Adenosyl-L-methionine disulfate tosylate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine disulfate 4-methylbenzenesulfonate
• Molecular Formula: C₁₅H₂₂N₆O₅S^.2(H₂SO₄)^.C₇H₈SO₃
• Molecular Weight: 766.79
• CAS Registry Number: 97540-22-2
• EC Number: 810-270-9
• SMILES: Cc1ccc(cc1)S(=O)(=O)O.C[S+](CC[C@@H](C(=O)O)N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O.OS(=O)(=O)O.OS(=O)(=O)[O-]

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318
Skin corrosion	Skin Corr.	1B	H314

Discovory and Applicatios

Ademetionine disulfate tosylate, commonly known as SAMe (S-adenosyl-L-methionine), is an important biochemical compound that has garnered significant attention in both medical and pharmaceutical fields due to its potential therapeutic properties. It is a naturally occurring compound in the human body and plays a crucial role in various biochemical processes, including methylation reactions, synthesis of neurotransmitters, and regulation of gene expression. The discovery and subsequent applications of SAMe have led to its widespread use as a therapeutic agent, particularly in the treatment of liver disorders, depression, and osteoarthritis.

The discovery of SAMe dates back to the 1950s when researchers identified its presence in living organisms. It was first synthesized in the laboratory as a derivative of methionine, an essential amino acid. The compound’s role as a methyl donor in biochemical reactions was quickly recognized, particularly in processes related to DNA methylation and the regulation of various enzymes. SAMe is synthesized in the body from methionine in the presence of adenosine triphosphate (ATP), and it is involved in the transfer of a methyl group (-CH3) to a wide range of molecules, including DNA, proteins, and lipids. This methylation process is essential for the proper functioning of cells and tissues, as it affects gene expression and protein function.

One of the most prominent applications of ademetionine disulfate tosylate is in the treatment of liver disorders, particularly in conditions such as cirrhosis and alcoholic liver disease. SAMe has been shown to help improve liver function by increasing the production of glutathione, a powerful antioxidant that plays a crucial role in detoxifying the liver. Studies have indicated that SAMe supplementation can enhance liver regeneration, protect liver cells from oxidative damage, and reduce inflammation. As a result, SAMe has become a popular adjunctive treatment in the management of chronic liver diseases, particularly in Europe and South America.

In addition to its liver-protective effects, ademetionine disulfate tosylate has also been studied for its potential in treating mood disorders, especially depression. SAMe is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are critical for mood regulation. Clinical studies have demonstrated that SAMe supplementation can have antidepressant effects, with some studies showing comparable efficacy to conventional antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs). As a result, SAMe has been used as a treatment for major depressive disorder, particularly in individuals who do not respond well to traditional antidepressant therapies.

Furthermore, SAMe has shown promise in the management of osteoarthritis, a degenerative joint disease characterized by cartilage breakdown and inflammation. SAMe’s anti-inflammatory properties, as well as its ability to promote cartilage repair, have made it a valuable therapeutic option for patients with osteoarthritis. Several studies have reported that SAMe supplementation can reduce pain, improve joint function, and slow the progression of the disease. It is often used as an alternative to nonsteroidal anti-inflammatory drugs (NSAIDs), which can have significant side effects when used long-term.

Beyond these primary uses, ademetionine disulfate tosylate has also been investigated for a variety of other potential applications. It has been studied for its neuroprotective effects in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, due to its role in maintaining brain health and supporting cellular repair processes. Additionally, SAMe has been explored for its potential to improve cognitive function, promote healthy aging, and support cardiovascular health.

Ademetionine disulfate tosylate is generally considered safe when used as directed, although side effects such as gastrointestinal discomfort, headaches, and anxiety have been reported in some individuals. It is important for patients to consult with a healthcare provider before using SAMe, especially if they are pregnant, breastfeeding, or taking other medications. Research on SAMe continues to explore its full therapeutic potential, and it remains a valuable compound in both clinical and experimental settings.

In conclusion, ademetionine disulfate tosylate (SAMe) is a naturally occurring compound with a wide range of therapeutic applications. From its role in liver health and mood disorders to its use in osteoarthritis treatment, SAMe has proven to be a valuable tool in modern medicine. Ongoing research continues to shed light on its broader potential, ensuring that it remains an important subject of interest in the pharmaceutical industry.