Octadecanol
[CAS# 112-92-5]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives >> Acyclic alcohol
• Name: Octadecanol
• Synonyms: 1-Hydroxyoctadecane; Stearyl alcohol; Octadecyl alcohol; Stearol
• Molecular Formula: C₁₈H₃₈O
• Molecular Weight: 270.50
• CAS Registry Number: 112-92-5
• EC Number: 204-017-6
• SMILES: CCCCCCCCCCCCCCCCCCO

Properties

• Density: 0.812
• Melting point: 55-58 ºC
• Boiling point: 336 ºC
• Flash point: 185 ºC
• Water solubility: insoluble

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Hazard Statements: H319-H335-H400-H410-H411-H412
• Precautionary Statements: P261-P264+P265-P271-P273-P280-P304+P340-P305+P351+P338-P319-P337+P317-P391-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Specific target organ toxicity - single exposure	STOT SE	3	H335
Specific target organ toxicity - single exposure	STOT SE	3	H336
Flammable liquids	Flam. Liq.	2	H225
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H302
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2A	H319

• Transport Information: UN 1986

Discovory and Applicatios

Stearyl alcohol, also known as Octadecanol, is a long-chain fatty alcohol with the chemical formula C18H38O. It was discovered during the study of fatty acids and their derivatives in the early 19th century. Stearyl alcohol is derived from stearic acid, a common saturated fatty acid from which stearyl alcohol can be synthesized. Stearic acid itself is found in natural fats and oils, especially from animals and some plants.

Stearyl alcohol is a waxy white solid at room temperature with a melting point of about 60°C. It is insoluble in water but soluble in organic solvents such as ethanol and ether. Its long hydrophobic carbon chain and hydrophilic hydroxyl groups give it an amphiphilic nature that can be used in a variety of applications that require surfactants.

One of the main uses of stearyl alcohol is in the cosmetics industry. Stearyl alcohol is used as an emulsifier and thickener in creams, lotions, and other personal care products. It helps stabilize emulsions, ensuring that the oil and water components do not separate. It provides structure and stability to lipsticks and deodorants, making them smooth to apply and consistent in texture.

Stearyl alcohol is used as an effective lubricant in a variety of industrial applications. It is used in metalworking fluids to reduce friction and wear on cutting tools and workpieces. Stearyl alcohol is used as a lubricant in textile and leather processing, helping machinery run smoothly and improving the feel of the final product.

Stearyl alcohol is used in surface coatings and polishes, and its hydrophobic nature makes it an excellent ingredient in car and furniture polishes, providing protection and gloss. In the paper industry, it imparts water-resistant properties to paper products.

Stearyl alcohol is used in the pharmaceutical industry as an ingredient in medicinal ointments and creams, where it acts as an emollient and stabilizer. Stearyl alcohol is used in controlled-release drug formulations to help regulate the release rate of active ingredients.

In the food industry, stearyl alcohol is used as an additive. It is used as an emulsifier in foods, ensuring that ingredients are stably mixed, otherwise they would separate. Stearyl alcohol can be used in food coatings to improve texture and appearance.

Stearyl alcohol has a variety of industrial applications. It is used as a plasticizer in plastic production to improve flexibility and durability. Stearyl alcohol is used in defoamers to reduce foam formation in industrial processes such as fermentation and wastewater treatment.

Stearyl alcohol is generally considered safe for use in cosmetics and pharmaceuticals. However, as with any chemical, proper handling and storage are important. It should be stored in a cool, dry place away from sources of ignition. Although stearyl alcohol is not highly toxic, contact with eyes or skin may cause irritation and ingestion of large amounts should be avoided.

Stearyl alcohol is biodegradable and poses minimal risk to the environment if used and handled properly. However, local regulations and handling guidelines must be followed to prevent any potential environmental contamination.

References

1969. Dermatitis From Cetyl and Stearyl Alcohols. Archives of Dermatology, 99(5).
DOI: 10.1001/archderm.1969.01610230085016

1970. Physical and functional properties of some higher alkyl polyglucosides. Journal of the American Oil Chemists' Society, 47(5).
DOI: 10.1007/bf02638743

2016. Identification of long chain specific aldehyde reductase and its use in enhanced fatty alcohol production in E. coli. Metabolic Engineering, 37.
DOI: 10.1016/j.ymben.2016.04.003