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Doramectin
[CAS# 117704-25-3]

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Complete supplier list of Doramectin
Identification
Classification API >> Antiparasitic drug >> Anthelmintic medications
Name Doramectin
Synonyms (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-cyclohexyl-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
Molecular Structure CAS # 117704-25-3, Doramectin, (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-cyclohexyl-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
Molecular Formula C50H74O14
Molecular Weight 899.11
CAS Registry Number 117704-25-3
EC Number 601-490-4
SMILES C[C@H]1/C=C/C=C/2\CO[C@H]3[C@@]2([C@@H](C=C([C@H]3O)C)C(=O)O[C@H]4C[C@@H](C/C=C(/[C@H]1O[C@H]5C[C@@H]([C@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)OC)\C)O[C@]7(C4)C=C[C@@H]([C@H](O7)C8CCCCC8)C)O
Properties
Density 1.3±0.1 g/cm3, Calc.*
Index of Refraction 1.580, Calc.*
Boiling Point 967.4±65.0 ºC (760 mmHg), Calc.*
Flash Point 274.4±27.8 ºC, Calc.*
* Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbols symbol symbol symbol symbol   GHS06;GHS07;GHS08;GHS09 Danger    Details
Hazard Statements H300-H301-H302-H360-H361-H362-H370-H372-H400-H410    Details
Precautionary Statements P203-P260-P263-P264-P270-P273-P280-P301+P316-P301+P317-P308+P316-P318-P319-P321-P330-P391-P405-P501    Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Chronic hazardous to the aquatic environmentAquatic Chronic1H410
Acute hazardous to the aquatic environmentAquatic Acute1H400
Acute toxicityAcute Tox.3H301
Specific target organ toxicity - single exposureSTOT SE1H370
Reproductive toxicityRepr.1BH360
Reproductive toxicityLact.-H362
Acute toxicityAcute Tox.4H302
Specific target organ toxicity - repeated exposureSTOT RE1H372
Acute toxicityAcute Tox.2H300
Reproductive toxicityRepr.2H361
Acute toxicityAcute Tox.3H331
Acute toxicityAcute Tox.1H300
SDS Available
up Discovory and Applicatios
Doramectin, a member of the avermectin class of compounds, was discovered through research efforts aimed at developing novel antiparasitic agents. It was first synthesized and characterized by scientists at Merck & Co. in the late 1980s. The discovery of doramectin stemmed from the screening of fermentation products derived from Streptomyces avermitilis, a soil bacterium known for producing potent anthelmintic compounds. Doramectin emerged as a promising candidate due to its potent antiparasitic activity and favorable pharmacokinetic properties.

Doramectin is widely used in veterinary medicine for the treatment and control of parasitic infections in livestock, including cattle, sheep, and swine. It is effective against a broad spectrum of internal and external parasites, including gastrointestinal nematodes, lungworms, mites, and ticks. Doramectin's efficacy in controlling parasitic infections contributes to improved animal health and productivity in livestock farming operations. In addition to livestock, doramectin is also used in companion animals, particularly in dogs and horses, for the prevention and treatment of parasitic infestations. It is effective against common parasites such as heartworms, intestinal worms, mites, and ticks. Doramectin formulations for companion animals are available in various formulations, including oral and topical preparations. Doramectin's broad spectrum of activity extends to wildlife species susceptible to parasitic infections. Wildlife conservationists and veterinarians utilize doramectin to control parasites in captive and free-ranging wildlife populations, contributing to the preservation of biodiversity and ecosystem health. The control of parasites in livestock and companion animals with doramectin also has indirect benefits for public health. By reducing the prevalence of zoonotic parasites and limiting the spread of parasitic diseases from animals to humans, doramectin plays a role in safeguarding public health and minimizing the risk of transmission of parasitic infections.

References

2016. Finafloxacin. Pharmaceutical Substances.
URL: https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-06-0134

2020. Synthetic Approaches to Contemporary Drugs that Contain the Cyclopropyl Moiety. Synthesis, 52(11).
DOI: 10.1055/s-0039-1690058
Market Analysis Reports
List of Reports Available for Doramectin
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