Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
[CAS# 1262046-34-3]

Identification

• Classification: Organic raw materials >> Aryl compounds >> Biphenyl compounds
• Name: Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
• Synonyms: ditert-butyl-[6-methoxy-3-methyl-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
• Molecular Formula: C₃₁H₄₉OP
• Molecular Weight: 468.69
• CAS Registry Number: 1262046-34-3
• EC Number: 805-149-2
• SMILES: CC1=C(C(=C(C=C1)OC)P(C(C)(C)C)C(C)(C)C)C2=C(C=C(C=C2C(C)C)C(C)C)C(C)C

Properties

• Solubility: Insoluble (7.0E^-6 g/L) (25 ºC), Calc.^*
• elting point: 129-130 ºC

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2013 ACD/Labs)

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H315-H319-H335
• Precautionary Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319

Discovory and Applicatios

Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine is a complex organophosphorus compound with significant applications in modern chemistry, particularly in the field of catalysis. This molecule is characterized by its bulky and highly branched structure, which includes a phosphine group attached to a biphenyl core that is further substituted with multiple alkyl and methoxy groups.

The discovery of this compound is tied to the ongoing development of specialized ligands for use in transition metal catalysis. Phosphine ligands are essential in catalysis because they can fine-tune the electronic and steric environment around a metal center, thereby influencing the reactivity and selectivity of catalytic reactions. The introduction of bulky substituents, such as the tert-butyl groups and isopropyl groups in this molecule, was aimed at creating a ligand that could provide greater control over these parameters, leading to improved performance in catalytic processes.

One of the primary applications of Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine is in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura and Heck reactions. These reactions are crucial for forming carbon-carbon bonds, a fundamental step in the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and advanced materials. The bulky nature of this phosphine ligand helps to stabilize the palladium catalyst, preventing its deactivation and enhancing the efficiency of the coupling reactions. Moreover, the steric hindrance introduced by the bulky groups can increase the selectivity of the catalyst, leading to higher yields of the desired products with fewer side reactions.

Beyond its role in cross-coupling reactions, this phosphine compound is also of interest in the development of new catalytic systems for asymmetric synthesis. The ability to create a chiral environment around the metal center is critical in producing enantiomerically pure compounds, which are essential in the development of drugs with specific biological activities. The large, branched substituents in this ligand can help to create a chiral pocket that influences the stereochemistry of the reaction, making it a valuable tool in the synthesis of chiral molecules.

In addition to its applications in catalysis, Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine is also being studied for its potential use in the creation of new materials. The unique structure of the compound allows it to interact with metals in ways that could lead to the development of novel materials with enhanced electronic, magnetic, or optical properties. Such materials could have applications in fields ranging from electronics to energy storage.

In summary, Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine is a highly specialized phosphine ligand with important applications in catalysis and materials science. Its discovery has contributed to advancements in the synthesis of complex organic molecules and the development of new catalytic systems, highlighting its significance in both academic research and industrial applications.

References

Hartwig, J.F., 2008. Organotransition Metal Chemistry: From Bonding to Catalysis. University Science Books, Sausalito.

Nolan, S.P., 2006. N-Heterocyclic Carbenes in Synthesis. Wiley-VCH, Weinheim.

Miura, M., and Nomura, M., 2002. Advances in Cross-Coupling Reactions. Chemical Reviews, 102(7), pp. 2751-2772.