2-(4-Propylcyclohexyl)propane-1,3-diol
[CAS# 132310-86-2]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Alcohol
• Name: 2-(4-Propylcyclohexyl)propane-1,3-diol
• Synonyms: trans-2-(4-Propylcyclohexyl)propane-1,3-diol
• Molecular Formula: C₁₂H₂₄O₂
• Molecular Weight: 200.32
• CAS Registry Number: 132310-86-2
• SMILES: CCCC1CCC(CC1)C(CO)CO

Properties

• Density: 1.0±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.476, Calc.^*
• Boiling Point: 320.6±10.0 ºC (760 mmHg), Calc.^*
• Flash Point: 146.8±13.6 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Discovory and Applicatios

2-(4-Propylcyclohexyl)propane-1,3-diol is an organic compound characterized by its combination of a cyclohexyl group and a propane-1,3-diol backbone. It was first synthesized in the early 2000s and has since been studied for its potential applications in various fields, particularly in materials science and polymer chemistry. The compound’s unique structure, which integrates a bulky cyclohexyl ring with a hydrophilic diol group, lends it certain desirable properties that make it useful in a variety of industrial processes.

The synthesis of 2-(4-propylcyclohexyl)propane-1,3-diol typically involves the selective functionalization of cyclohexene derivatives with a propylene glycol component. This reaction introduces the propyl group onto the cyclohexyl ring, creating a molecule with both hydrophobic and hydrophilic regions. The structure of the compound enables it to interact effectively with various substances, which is essential for its use as a plasticizer and stabilizer in polymer formulations. Its presence in polyolefins, for example, can enhance their flexibility, thermal stability, and resistance to degradation, making the resulting polymers more durable and longer-lasting.

In addition to its uses in polymer science, 2-(4-propylcyclohexyl)propane-1,3-diol has been explored for applications in lubricants, coatings, and other industrial products. Its ability to perform well under high-stress conditions makes it an attractive additive in these areas, helping to improve the performance and longevity of lubricants and coatings in demanding environments. The compound’s hydrophilic nature also makes it useful in drug delivery systems. Research has shown that it can improve the solubility and bioavailability of poorly water-soluble drugs, which is beneficial in the formulation of more effective pharmaceutical products.

Further studies are ongoing to explore the broader potential applications of 2-(4-propylcyclohexyl)propane-1,3-diol, particularly in the development of new materials and drug formulations. Its unique structure and properties offer significant advantages over traditional compounds in various industrial and medical contexts.