3-Phenylbenzyl bromide
[CAS# 14704-31-5]

Identification

• Classification: Organic raw materials >> Hydrocarbon compounds and their derivatives >> Hydrocarbon halide
• Name: 3-Phenylbenzyl bromide
• Synonyms: 3-(Bromomethyl)biphenyl
• Molecular Formula: C₁₃H₁₁Br
• Molecular Weight: 247.13
• CAS Registry Number: 14704-31-5
• EC Number: 629-083-7
• SMILES: C1=CC=C(C=C1)C2=CC=CC(=C2)CBr

Properties

• Melting point: 57-61 ºC

Safety Data

• Hazard Symbols: GHS05;GHS07;GHS09 Danger
• Hazard Statements: H302-H314-H400-H410
• Precautionary Statements: P260-P264-P270-P273-P280-P301+P317-P301+P330+P331-P302+P361+P354-P304+P340-P305+P354+P338-P316-P321-P330-P363-P391-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Skin corrosion	Skin Corr.	1B	H314
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315

• Transport Information: UN 3261

Discovory and Applicatios

3-Phenylbenzyl bromide is a versatile organic compound that plays a significant role in synthetic chemistry and medicinal chemistry. This compound features a benzyl bromide group attached to a phenyl ring, offering unique reactivity and utility in various chemical transformations.

The discovery of 3-Phenylbenzyl bromide emerged from ongoing research into the functionalization of aromatic compounds. Its synthesis typically involves the bromination of 3-phenylbenzyl alcohol or related precursors, where the introduction of the bromine atom is achieved through standard halogenation techniques. The resulting compound is a valuable intermediate in the synthesis of more complex molecules due to its reactivity and functional group compatibility.

One of the key applications of 3-Phenylbenzyl bromide is in organic synthesis, where it serves as a crucial building block for creating various chemical entities. Its primary utility lies in its role as an electrophile in nucleophilic substitution reactions. The bromide group can be readily displaced by nucleophiles, leading to the formation of new carbon-nucleophile bonds. This characteristic makes 3-Phenylbenzyl bromide valuable for constructing diverse organic molecules, including pharmaceuticals, agrochemicals, and materials.

In medicinal chemistry, 3-Phenylbenzyl bromide has been employed as a precursor for the synthesis of biologically active compounds. It has been used to introduce the phenyl group into drug molecules or to modify existing pharmacophores, enhancing their biological activity or altering their pharmacokinetic properties. The bromide functionality allows for the facile attachment of various functional groups, enabling the creation of a wide range of analogs for biological testing and drug development.

Moreover, 3-Phenylbenzyl bromide is also utilized in the synthesis of functionalized polymers and materials. The ability to introduce the phenyl group into polymer backbones or copolymer structures can impart specific properties, such as enhanced rigidity or improved electronic characteristics. This makes 3-Phenylbenzyl bromide a useful reagent in materials science and polymer chemistry.

The compound's reactivity in nucleophilic substitution reactions is influenced by the electronic properties of the phenyl group and the bromide leaving group. The phenyl group, being electron-donating, can stabilize the transition state of the nucleophilic attack, while the bromide atom, as a good leaving group, facilitates the substitution process. This interplay of electronic effects makes 3-Phenylbenzyl bromide a valuable tool for chemists aiming to develop new chemical transformations or functional materials.

Overall, 3-Phenylbenzyl bromide represents an important reagent in organic and medicinal chemistry. Its discovery and application highlight its versatility as a chemical intermediate, offering significant utility in the synthesis of complex molecules and functional materials.

References

1986. A new host compound for the selective inclusion of ethanol. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 4, 2.
DOI: 10.1007/bf00655930